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The Hallmarks of Cancer
TLDR
This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute. Expand
Hallmarks of Cancer: The Next Generation
TLDR
Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. Expand
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
TLDR
It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells. Expand
The basics of epithelial-mesenchymal transition.
TLDR
Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes. Expand
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
TLDR
A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT). Expand
The Biology of Cancer
TLDR
This book presents a meta-anatomy of Tumor Immunology and Immunotherapy, focusing on the role of immune checkpoints in the development of tumourigenesis and the maintenance of Genomic Integrity. Expand
The retinoblastoma protein and cell cycle control
TLDR
The main role of pRB is to act as a signal transducer connecting the cell cycle clock with the transcriptional machinery, allowing the clock to control the expression of banks of genes that mediate advance of the cell through a critical phase of its growth cycle. Expand
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
TLDR
Owing to the importance of these tumour-associated phenotypes in metastasis and cancer-related mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients. Expand
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
TLDR
Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients. Expand
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.
TLDR
This review summarizes and compares major signaling pathways that regulate the epithelial-mesenchymal transitions during both development and tumor metastasis and examines their role in carcinoma invasion and metastasis. Expand
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