H. Tsuda

Publications721
h-index80
Citations24,745
Highly Influential Citations854
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KIF5B-RET fusions in lung adenocarcinoma
TLDR
In-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene are identified and a RET tyrosine kinase inhibitor, vandetanib, suppresses the fusion-induced anchorage-independent growth activity of NIH3T3 cells.
One-step Nucleic Acid Amplification for Intraoperative Detection of Lymph Node Metastasis in Breast Cancer Patients
TLDR
Clinical results indicate that the OSNA assay provides a useful intraoperative detection method of lymph node metastasis in breast cancer patients, and results similar to those of three-level histopathology.
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
TLDR
It is suggested that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.
Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
TLDR
Findings suggest that exosomal transfer of miRNAs from the bone marrow may promote breast cancer cell dormancy in a metastatic niche.
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women.
TLDR
The efficacy of fertility-sparing treatment with a high-dose of MPA for EC and AH was proven by this prospective trial, however, close follow-up is required because of the substantial rate of recurrence.
Beta-catenin mutation in carcinoma of the uterine endometrium.
TLDR
Investigation of mutations in exon 3 of the beta-catenin gene in endometrial carcinoma cases in which loss of heterozygosity at the adenomatous polyposis coli tumor suppressor gene locus has been rarely reported indicates that stabilization of beta-Catenin due to mutations inExon 3of the beta/threonine residues and other mechanisms may have an important role in development of endometrian carcinomas.
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma
TLDR
The results suggest that somatic mutations of the PIK3CA gene are likely to occur late in the development of OSCC, and play a crucial role through the PI3K–AKT signaling pathway in cancer progression.
High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway
TLDR
Through gene ontology and pathway analyses, a significant reduction in expression of immune-response–related genes, especially on the antigen presentation pathway, in high-risk ovarian cancer patients is identified.
Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas
TLDR
Multivariate analysis showed that a combination of these 2 patterns was the most powerful histologic indicator of ALK rearrangement, and histomorphology should not replace confirmatory molecular or immunohistochemical studies.
Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.
TLDR
Cox's life-table regression analysis showed that amplification of c-erbB-2 had a prognostic value, which was independent of other known prognostic factors such as lymph node status and tumor size.
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