S. Hirohashi

Publications707
h-index111
Citations46,457
Highly Influential Citations1,285
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Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
The histological variability of solitary fibrous tumors may contribute to the difficulty in diagnosing these neoplasms, especially when they arise in extrathoracic sites. Like intrathoracic lesions,… Expand
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  • 31
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide association study (stage 1: 85,576 SNPs on 188… Expand
  • 330
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Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.
Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar epidermoid carcinoma A-431… Expand
  • 595
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Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
The nuclear factor E2-related factor 2 (Nrf2) is a master transcriptional activator of genes encoding numerous cytoprotective enzymes that are induced in response to environmental and endogenously… Expand
  • 558
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Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Regulation of the actin cytoskeleton may play a crucial role in cell motility and cancer invasion. We have produced a monoclonal antibody (NCC- Lu-632, IgM, k) reactive with an antigenic protein that… Expand
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Small adenocarcinoma of the lung. Histologic characteristics and prognosis
Background. Although there are many reported prognostic indicators for pulmonary adenocarcinoma, the clinicopathologic characteristics and prognostic factors of early stage adenocarcinoma have not… Expand
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Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
  • S. Hirohashi
  • Medicine, Biology
  • The American journal of pathology
  • 1 August 1998
It has long been known that cell-cell adhesiveness is generally reduced in human cancers. Tumor cells are dissociated throughout the entire tumor masses of diffuse-type cancers, whereas those of… Expand
  • 862
  • 22
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and human epidermal growth factor receptor 2 (HER2) have been considered as potential therapeutic targets in… Expand
  • 249
  • 19
Proximal-Type Epithelioid Sarcoma: A Clinicopathologic Study of 20 Cases
We studied the clinicopathologic and immunohistochemical features of 20 cases of proximal-type epithelioid sarcoma to identify prognostic factors. The 20 patients ranged in age from 13 to 80 years… Expand
  • 179
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Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions
Purpose: Antitumor immune response changes drastically during the progression of cancers. Established cancers often escape from the host immune system, although specific immune surveillance operates… Expand
  • 599
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