S. Hirohashi

Publications710
h-index116
Citations50,706
Highly Influential Citations1,373
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Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial
Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.
Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar epidermoid carcinoma A-431…
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
TLDR
It is found that PSCA is expressed in differentiating gastric epithelial cells, has a cell-proliferation inhibition activity in vitro and is frequently silenced in gastric cancer.
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
TLDR
In human cancer, somatic mutations occur in the coding region of NRF2, especially among patients with a history of smoking or suffering from squamous cell carcinoma; in the latter case, this leads to poor prognosis.
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
  • S. Hirohashi
  • Biology, Medicine
    The American journal of pathology
  • 1 August 1998
Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions
TLDR
TR play a role in controlling the immune response against pancreatic ductal carcinoma from the premalignant stage to established cancer, and a high prevalence of TR seems to be a marker of poor prognosis.
Small adenocarcinoma of the lung. Histologic characteristics and prognosis
TLDR
The clinicopathologic characteristics and prognostic factors of early stage adenocarcinoma have not been evaluated fully, except for several studies of nonmucinous and sclerosing bronchioloalveolar carcinoma.
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
TLDR
It is suggested that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.
Proximal-Type Epithelioid Sarcoma: A Clinicopathologic Study of 20 Cases
TLDR
It is concluded that proximal-type epithelioid sarcomas are rare, undifferentiated soft-tissue sarcoma of adults, with epithelIOid features and a frequent rhabdoid phenotype, and have a much worse prognosis than those arising in distal locations.
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