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Proto-Oncogenes

Known as: c-ONC, Cellular Oncogene, Cellular Oncogenes 
Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (13)

BCL2 protein, humanCSF1R geneERBB2 geneFOS Family Genes
Gene Mutationaspects of radiation effectsphysiological aspects

Broader (1)

Genes

Papers overview

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Highly Cited
2007
Highly Cited
2007
An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation.
Guanine-rich nucleic acid sequences can adopt noncanonical four-stranded secondary structures called guanine (G)-quadruplexes… 
Highly Cited
1994
Highly Cited
1994
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
The bmi-1 proto-oncogene has been implicated in B-cell lymphomagenesis in E mu-myc transgenic mice. Distinct domains of the Bmi-1… 
Highly Cited
1994
Highly Cited
1994
Mutation of the proto‐oncogene c‐kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.
1. Interstitial cells of Cajal (ICs) have been proposed as pacemakers in the gastrointestinal tract. We studied the… 
Highly Cited
1994
Highly Cited
1994
Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
We have analysed 118 families with inherited medullary thyroid carcinoma (MTC) for mutations of the RET proto–oncogene. These… 
Highly Cited
1992
Highly Cited
1992
Cooperative interaction between c-myc and bcl-2 proto-oncogenes
THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene… 
Highly Cited
1990
Highly Cited
1990
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
THE int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours1,2. Expression studies… 
Highly Cited
1990
Highly Cited
1990
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
Highly Cited
1990
Highly Cited
1990
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr… 
Highly Cited
1988
Highly Cited
1988
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
Mice carrying mutations at the W locus located on chromosome 5 are characterized by severe macrocytic anaemia, lack of hair… 
Highly Cited
1982
Highly Cited
1982
Mechanism of activation of a human oncogene
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are… 
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