Proto-Oncogenes

Known as: c-ONC, Cellular Oncogene, Cellular Oncogenes 
Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in cancer and typically correlates with… (More)
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Highly Cited
2009
Highly Cited
2009
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein… (More)
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Highly Cited
2001
Highly Cited
2001
Genomic instability promotes tumorigenesis and can occur through various mechanisms, including defective segregation of… (More)
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Highly Cited
1993
Highly Cited
1993
MULTIPLE endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome that affects tissues derived from neural… (More)
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Highly Cited
1992
Highly Cited
1992
THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene… (More)
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Highly Cited
1991
Highly Cited
1991
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145… (More)
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Highly Cited
1991
Highly Cited
1991
To understand the normal, physiological role of the c-src proto-oncogene, a null mutation was introduced into the gene by… (More)
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Highly Cited
1989
Highly Cited
1989
Carcinoma of the breast and ovary account for one-third of all cancers occurring in women and together are responsible for… (More)
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Highly Cited
1989
Highly Cited
1989
DNA clones of the wild-type p53 proto-oncogene inhibit the ability of E1A plus ras or mutant p53 plus ras-activated oncogenes to… (More)
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Highly Cited
1985
Highly Cited
1985
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived… (More)
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