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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210bCr-abl and p185bcr-abl proteins.
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
It is suggested that oligomersization of TEL-ABL mediated by the TEL HLH domain is required for tyrosine kinase activation, cytoskeletal localization, and transformation, and that oligomerization of Ets proteins through the highly conserved HLHdomain may represent a previously unrecognized phenomenon.
Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases
The activated BTK was predominantly membrane-associated, which suggests that BTK integrates distinct receptor signals resulting in SRC kinase activation and BTK membrane targeting.
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.
  • R. Reiter, Z. Gu, O. Witte
  • Biology
    Proceedings of the National Academy of Sciences…
  • 17 February 1998
Flow cytometric analysis demonstrates that PSCA is expressed predominantly on the cell surface and is anchored by a GPI linkage, which supports P SCA as a target for prostate cancer diagnosis and therapy.
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
Prostate cancer mortality results from metastasis to bone and hormone-independent tumor growth. Models to study these progressive changes are lacking. Here we describe the propagation of advanced
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics
The epithelium of the adult prostate contains 3 distinct cell types: basal, luminal, and neuroendocrine. Tissue-regenerative activity has been identified predominantly from the basal cells, isolated
The BCR-ABL story: bench to bedside and back.
Analysis of CML patients resistant to BCR-ABL suppression by Imatinib mesylate coupled with the crystallographic structure of ABL complexed to this inhibitor have shown how structural mutations in ABL can circumvent an otherwise potent anticancer drug.
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.
By analogy to the gag/abl fusion protein of Abelson murine leukemia virus, the replacement of amino terminal c-abl sequences by bcr sequences in P210 may create a transforming protein involved in CML.
Isolation and functional characterization of murine prostate stem cells
In vitro prostate colony- and sphere-forming assays were used to quantitatively measure murine prostate stem/progenitor cell enrichment and self-renewal and the remarkable similarity in cell surface profile between prostate and mammary gland stem cells suggests these markers may be conserved among epithelial stem cell populations.