Mechanism of activation of a human oncogene

  title={Mechanism of activation of a human oncogene},
  author={Clifford J Tabin and Scott M. Bradley and Cornelia I Bargmann and Robert A Weinberg and Alex G. Papageorge and Edward M. Scolnick and Ravi Dhar and Douglas R Lowy and Esther H. Chang},
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein. 

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 144 extracted citations

Cancer genes generated by rare chromosomal rearrangements rather than activation of oncogenes.

Medical oncology and tumor pharmacotherapy • 1987
View 4 Excerpts
Highly Influenced

Are activated proto-onc genes cancer genes?

Haematology and blood transfusion • 1985
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…