Mechanism of activation of a human oncogene

@article{Tabin1982MechanismOA,
  title={Mechanism of activation of a human oncogene},
  author={Clifford J Tabin and Scott M. Bradley and Cornelia I Bargmann and Robert A Weinberg and Alex G. Papageorge and Edward M. Scolnick and Ravi Dhar and Douglas R Lowy and Esther H. Chang},
  journal={Nature},
  year={1982},
  volume={300},
  pages={143-149}
}
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein. 

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