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BCL2 protein, human

Known as: B-Cell CLL/lymphoma 2, B-cell CLL-lymphoma 2 protein, human, B-cell leukemia/lymphoma 2 protein 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (4)

ApoptosisB-Cell Leukemia 2 Family ProteinsProto-Oncogene Proteins c-bcl-2Proto-Oncogenes
Apoptosis InhibitorB-Cell ActivationBCL2 geneBCL2 wt Allele

Papers overview

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Highly Cited
1999
Highly Cited
1999
bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis.
Highly Cited
1998
Highly Cited
1998
Differentiation of odontogenic keratocysts from other odontogenic cysts by the expression of bcl-2 immunoreactivity.
Highly Cited
1998
Highly Cited
1998
Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant glioma cells: association with bcl-2 phosphorylation but neither activation of p53 nor G2/M cell cycle arrest.
The anti-tumour alkaloid taxol shows strong cytotoxic and antiproliferative activity in two human malignant glioma cell lines… 
Highly Cited
1997
Highly Cited
1997
Suppression of nitric oxide–induced apoptosis by N‐acetyl‐l‐cysteine through modulation of glutathione, bcl‐2, and bax protein levels
It has been demonstrated that nitric oxide (NO) can promote apoptosis in human cancer cells. To test the protective effects of… 
Highly Cited
1996
Highly Cited
1996
Expression of bcl-2 and the progression of human and rodent prostatic cancers.
The frequency of bcl-2 protein expression was evaluated using immunocytochemical staining during the progression of human and rat… 
Highly Cited
1995
Highly Cited
1995
Immunohistochemical evaluation of bcl‐2 protein expression in gastric adenocarcinomas
Background, bcl‐2 protooncogene encodes for a 26 kD protein effective in inhibiting programmed cell death (apoptosis). Its… 
Highly Cited
1995
Highly Cited
1995
bcl-2 suppresses expression of p21WAF1/CIP1 in breast epithelial cells.
The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest… 
Highly Cited
1995
Highly Cited
1995
bcl-2 protein expression in melanocytic neoplasms of the skin.
Since the discovery of bcl-2 proto-oncogene in follicular lymphomas, the protein product has been detected in a variety of normal… 
Highly Cited
1994
Highly Cited
1994
Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2…
Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's… 
Highly Cited
1992
Highly Cited
1992
Prevention of programmed cell death in burkitt lymphoma cell lines by bcl‐2‐dependent and ‐independent mechanisms
Burkitt lymphoma (BL) cell lines which retain the phenotypic characteristics of the freshly‐isolated tumour cells (group I cells… 
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