BCL2 protein, human

Known as: B-Cell CLL/lymphoma 2, B-cell CLL-lymphoma 2 protein, human, B-cell leukemia/lymphoma 2 protein 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Several inhibitors of BCL2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their… (More)
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Highly Cited
2008
Highly Cited
2008
microRNAs are endogenous small noncoding RNAs that regulate gene expression negatively at posttranscriptional level. This latest… (More)
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Highly Cited
2006
Highly Cited
2006
B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B cells that are resistant to apoptosis… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Chemoresistance of malignant melanoma has been linked to expression of the proto-oncogene BCL2. Antisense… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE We studied the prognostic significance of bcl2 and p53 protein expression in relation to clinical and pathologic… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND In general, myocyte death in myocardial infarctions (MIs) is attributed to necrosis, but recently the involvement of… (More)
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Highly Cited
1995
Highly Cited
1995
Programmed cell death (apoptosis) is an active process by which cells initiate their own self-destruction. Growing evidence shows… (More)
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Highly Cited
1995
Highly Cited
1995
B lymphocytes recognize antigen through membrane-bound antigen-receptors, membrane IgM and IgD (mIgM and mIgD). Binding to… (More)
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Highly Cited
1993
Highly Cited
1993
The BCL-2 proto-oncogene encodes a mitochondrial protein that blocks programmed cell death. High amounts of bcl-2 protein are… (More)
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Highly Cited
1986
Highly Cited
1986
We have determined that the bcl-2 (B-cell leukemia/lymphoma 2) gene is transcribed into three overlapping mRNAs, and we have… (More)
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