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BCL2 gene

Known as: bcl-2 Gene, BCL2, Gene, bcl-2 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… 
National Institutes of Health

Related topics

Related topics

28 relations
ApoptosisB-Cell ActivationBCL2 Ag:PrThr:Pt:Tiss:Ord:Immune stainBCL2 Gene Rear Bld/T Ql

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c-bcl-2 Genes

Papers overview

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Highly Cited
2005
Highly Cited
2005
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Highly Cited
2005
Highly Cited
2005
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL… 
Highly Cited
1997
Highly Cited
1997
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents… 
Highly Cited
1997
Highly Cited
1997
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases… 
Highly Cited
1994
Highly Cited
1994
Disruption of epithelial cell-matrix interactions induces apoptosis
Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure… 
Highly Cited
1993
Highly Cited
1993
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Highly Cited
1993
Highly Cited
1993
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Highly Cited
1993
Highly Cited
1993
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
Highly Cited
1990
Highly Cited
1990
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
THE t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin… 
Review
1988
Review
1988
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
A common feature of follicular lymphoma, the most prevalent haematological malignancy in humans, is a chromosome translocation (t… 
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