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BCL2 gene

Known as: bcl-2 Gene, BCL2, Gene, bcl-2 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B… Expand
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Review
2019
Review
2019
Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma… Expand
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Review
2019
Review
2019
Regulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development… Expand
Review
2018
Review
2018
Cancer is a daunting global problem confronting the world's population. The most frequent therapeutic approaches include surgery… Expand
Review
2018
Review
2018
According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel… Expand
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Review
2018
Review
2018
Despite advances in the treatment of multiple myeloma, the disease still remains incurable for the majority of patients. The… Expand
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Highly Cited
1997
Highly Cited
1997
  • Jie Yang, Xuesong Liu, +6 authors Xiaodong Wang
  • Science
  • 1997
  • Corpus ID: 32349676
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents… Expand
Highly Cited
1997
Highly Cited
1997
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases… Expand
Highly Cited
1993
Highly Cited
1993
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we… Expand
Highly Cited
1990
Highly Cited
1990
THE t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin… Expand