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BCL2 gene

Known as: bcl-2 Gene, BCL2, Gene, bcl-2 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… Expand
National Institutes of Health

Related topics

Related topics

28 relations
ApoptosisB-Cell ActivationBCL2 Ag:PrThr:Pt:Tiss:Ord:Immune stainBCL2 Gene Rear Bld/T Ql
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c-bcl-2 Genes

Papers overview

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Review
2018
Review
2018
Bax, Bak and beyond - mitochondrial performance in apoptosis.
Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli… Expand
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Review
2017
Review
2017
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the process of controlled removal of… Expand
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Review
2017
Review
2017
JNK at the crossroad of obesity, insulin resistance, and cell stress response
BACKGROUND The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress response, with outcomes ranging from cell… Expand
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Highly Cited
2005
Highly Cited
2005
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis… Expand
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Highly Cited
2005
Highly Cited
2005
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL… Expand
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Highly Cited
1997
Highly Cited
1997
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents… Expand
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Highly Cited
1997
Highly Cited
1997
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases… Expand
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Highly Cited
1994
Highly Cited
1994
Disruption of epithelial cell-matrix interactions induces apoptosis
Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure… Expand
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Highly Cited
1993
Highly Cited
1993
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we… Expand
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Highly Cited
1990
Highly Cited
1990
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
THE t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin… Expand
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