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BCL2 gene

Known as: bcl-2 Gene, BCL2, Gene, bcl-2 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… Expand
National Institutes of Health

Related topics

Related topics

28 relations
ApoptosisB-Cell ActivationBCL2 Ag:PrThr:Pt:Tiss:Ord:Immune stainBCL2 Gene Rear Bld/T Ql
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c-bcl-2 Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
BCL-2 family isoforms in apoptosis and cancer
The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B… Expand
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Review
2019
Review
2019
Targeting the Bcl-2 Family in B Cell Lymphoma
Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma… Expand
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Review
2019
Review
2019
Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy.
Regulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development… Expand
Review
2018
Review
2018
Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer.
Cancer is a daunting global problem confronting the world's population. The most frequent therapeutic approaches include surgery… Expand
Review
2018
Review
2018
Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy
According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel… Expand
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Review
2018
Review
2018
Targeting Bcl-2 for the treatment of multiple myeloma
Despite advances in the treatment of multiple myeloma, the disease still remains incurable for the majority of patients. The… Expand
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Highly Cited
1997
Highly Cited
1997
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
  • Jie Yang, Xuesong Liu, +6 authors Xiaodong Wang
  • Science
  • 1997
    • Corpus ID: 32349676
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents… Expand
Highly Cited
1997
Highly Cited
1997
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases… Expand
Highly Cited
1993
Highly Cited
1993
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we… Expand
Highly Cited
1990
Highly Cited
1990
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
THE t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin… Expand
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