FAQ

BCL2 gene

Known as: bcl-2 Gene, BCL2, Gene, bcl-2 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
020406019882018

Related topics

Related topics

13 relations
ApoptosisB-Cell ActivationBCL2 protein, humanBCL2 wt Allele
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
BCL2 gene
physiological aspects
Apoptosis
Somatic mutation
Lymphoma, Follicular
B-Cell Activation

Papers overview

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Highly Cited
2013
Highly Cited
2013
MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma.
MYC rearrangements occur in 5% to 10% of diffuse large B-cell lymphomas (DLBCL) and confer an increased risk to cyclophosphamide… (More)
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Highly Cited
2010
Highly Cited
2010
BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received
Background:Breast cancer is heterogeneous and the existing prognostic classifiers are limited in accuracy, leading to unnecessary… (More)
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Highly Cited
2008
Highly Cited
2008
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells.
microRNAs are endogenous small noncoding RNAs that regulate gene expression negatively at posttranscriptional level. This latest… (More)
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Highly Cited
2006
Highly Cited
2006
BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma.
BACKGROUND The role of BCL2 as a predictor of survival in diffuse large B-cell lymphoma (DLBCL) is controversial. DLBCL is… (More)
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Highly Cited
2004
Highly Cited
2004
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed prognostically important subgroups: germinal… (More)
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Highly Cited
1998
Highly Cited
1998
Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma.
Diffuse large B-cell lymphoma (DLCL) is characterized by a marked degree of morphologic and clinical heterogeneity. We studied… (More)
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Highly Cited
1997
Highly Cited
1997
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma.
Gene activation by translocation between an oncogene and an immunoglobulin heavy-chain gene, which leads to increased expression… (More)
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1996
1996
BCL2 regulates neural differentiation.
A main function attributed to the BCL2 protein is its ability to confer resistance against apoptosis. In addition to the… (More)
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Highly Cited
1991
Highly Cited
1991
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an… (More)
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Highly Cited
1991
Highly Cited
1991
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from… (More)
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