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Apoptosis

Known as: Mechanism that allows cells to self-destruct when it is necessary, Programmed Cell Death, Type I, Programmed Cell Death 
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death… 
National Institutes of Health

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Related topics

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AATF geneADRA1A protein, humanAGTR2 geneANP32B wt Allele

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Apoptosis, Extrinsic Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative.
Estrogens are essential for normal reproductive function. In addition, they exert important, complex, and diverse nonreproductive… 
Highly Cited
2003
Highly Cited
2003
Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.
Highly Cited
2002
Highly Cited
2002
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells.
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that use 2 major pathways for antigen uptake: constitutive… 
Highly Cited
2000
Highly Cited
2000
MHC class I‐restricted killing of neurons by virus‐specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
Induction of MHC class I genes in neurons of the central nervous system requires signals by pro‐inflammatory cytokines, in… 
Review
2000
Review
2000
Estrogen receptor-mediated processes in normal and cancer cells.
The role of estrogens in breast and other cancers has been extensively investigated for many years, and historically most of… 
Review
1998
Review
1998
Simultaneous measurement of cell cycle and apoptotic cell death.
Highly Cited
1997
Highly Cited
1997
Role of Different T Cell Receptors in the Development of Pre–T Cells
The development of pre–T cells with productive TCR-β rearrangements can be mediated by each the pre–T cell receptor (pre-TCR… 
Highly Cited
1996
Highly Cited
1996
Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins*
Activation of the type I insulin-like growth factor receptor (IGF-IR) blocks osmotic mediated programmed cell death (PCD) in… 
Highly Cited
1994
Highly Cited
1994
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
Lymphocyte-mediated cytotoxicity has been proposed to consist of the polarized secretion of granule-stored perforin leading to… 
Highly Cited
1990
Highly Cited
1990
Gene activation is required for developmentally programmed cell death.
The intersegmental muscles of the tobacco hawkmoth Manduca sexta die during the 36-hr period after metamorphosis. The trigger for… 
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