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Apoptosis

Known as: Mechanism that allows cells to self-destruct when it is necessary, Programmed Cell Death, Type I, Programmed Cell Death 
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death… 
National Institutes of Health

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Apoptosis, Extrinsic Pathway

Papers overview

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Review
2003
Review
2003
Regulation of apoptosis by endoplasmic reticulum pathways
Apoptotic programmed cell death pathways are activated by a diverse array of cell extrinsic and intrinsic signals, most of which… 
Highly Cited
2001
Highly Cited
2001
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Programmed cell death is a fundamental requirement for embryogenesis, organ metamorphosis and tissue homeostasis. In mammals… 
Review
2000
Review
2000
The morphology of apoptosis
Abstract The concept of apoptotic cell death as an essential part of the development and life of complex organisms has been… 
Review
2000
Review
2000
14-3-3 proteins: structure, function, and regulation.
The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the… 
Highly Cited
2000
Highly Cited
2000
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway.
Dendritic cells (DC) are key components of innate and adaptive immune responses. The identity of endogenous signals that activate… 
Review
1998
Review
1998
Dysregulation of apoptosis in cancer.
Each day, approximately 50 to 70 billion cells perish in the average adult because of programmed cell death (PCD). Cell death in… 
Highly Cited
1996
Highly Cited
1996
Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor… 
Highly Cited
1996
Highly Cited
1996
Salmonella typhimurium invasion induces apoptosis in infected macrophages.
Invasive Salmonella typhimurium induces dramatic cytoskeletal changes on the membrane surface of mammalian epithelial cells and… 
Highly Cited
1995
Highly Cited
1995
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
RECEPTOR crosslinking of T-cell hybridomas induces cell activation followed by apoptosis1–6. This activation-induced cell death… 
Review
1992
Review
1992
Apoptosis and programmed cell death in immunity.
Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell… 
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