A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.

@article{Houenou1995ASP,
  title={A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.},
  author={Lucien J. Houenou and Patricia L. Turner and L Li and Ronald W. Oppenheim and Barry W Festoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 3},
  pages={895-9}
}
Protease nexin I (PNI) is a member of the family of serine protease inhibitors (serpins) that have been shown to promote neurite outgrowth in vitro from different neuronal cell types. These include neuroblastoma cells, hippocampal neurons, and sympathetic neurons. Free PNI protein is markedly decreased in various anatomical brain regions, including hippocampus, of patients with Alzheimer disease. Here, we report that PNI rescued spinal motoneurons during the period of naturally occurring… CONTINUE READING
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