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Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
VKORC1 haplotypes can be used to stratify patients into low-, intermediate-, and high-dose warfarin groups and may explain differences in dose requirements among patients of different ancestries.
Pharmacogenomics--drug disposition, drug targets, and side effects.
  • W. Evans, H. McLeod
  • Medicine, Biology
    The New England journal of medicine
  • 6 February 2003
The existence of large population differences with small intrapatient variability is consistent with inheritance as a determinant of drug response; it is estimated that genetics can account for 20 to 95 percent of variability in drug disposition and effects.
Doxorubicin pathways: pharmacodynamics and adverse effects
The goal of this study is to give a brief background on the literature supporting the PharmGKB pathway about doxorubicin action, and provides a summary of this active area of research. The reader is
Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs
It appears that the chemical properties of a drug critical to CYP3A4 inactivation include formation of reactive metabolites by CYP isoenzymes, preponderance of CYP inducers and P-glycoprotein (P-gp) substrate, and occurrence of clinically significant pharmacokinetic interactions with coadministered drugs.
MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.
The high frequency of the C allele in the African group implies overexpression of PGP and may have important therapeutic and prognostic implications for use of P GP dependent drugs in individuals of African origin.
Platinum neurotoxicity pharmacogenetics
Findings from the current literature for genetic markers associated with neurotoxicity induced by single-agent and combination platinum chemotherapy have the potential for broad clinical implications if mechanistic associations lead to the development of toxicity modulators to minimize the noxious sequelae of platinum chemotherapy.
Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes
The data suggest that patterns of differentiation and gene flow in Africa have differed for men and women in the recent evolutionary past, and infer that sex-biased rates of admixture and/or language borrowing between expanding Bantu farmers and local hunter-gatherers played an important role in influencing patterns of genetic variation during the spread of African agriculture in the last 4000 years.
The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.
DNA from 199 British Caucasian, 99 British South West Asian and 192 Chinese individuals was analysed for the presence of four variant thiopurine methyltransferase alleles, which suggests that A719G is the oldest mutation, with G460A being acquired later to form the TPMT*3A allele in the Caucasian and South WestAsian populations.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of