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Autophagy in the Pathogenesis of Disease
This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases. Expand
Mitochondrial membrane permeabilization in cell death.
Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise. Expand
Molecular characterization of mitochondrial apoptosis-inducing factor
The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death. Expand
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a type of cancer which can be difficult to treat with conventional chemotherapy. Expand
The Hallmarks of Aging
Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects. Expand
The Pathophysiology of Mitochondrial Cell Death
The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed. Expand
Calreticulin exposure dictates the immunogenicity of cancer cell death
It is shown that anthracyclin-induced CRT translocation induces the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and is identified as a key feature determining anticancer immune responses. Expand
Self-eating and self-killing: crosstalk between autophagy and apoptosis
The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation thatExpand
Mitochondrial control of cell death
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, asExpand
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described. Expand