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Proto-Oncogene Proteins c-bcl-2

Known as: c-bcl-2 Proteins, bcl-2 Proto-Oncogene Proteins, bcl 2 Proto Oncogene Proteins 
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Bcl-2 is an anti-apoptotic oncoprotein and its protein levels are inversely correlated with prognosis in many cancers. However… Expand
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Highly Cited
2002
Highly Cited
2002
Multiple myeloma (MM) is a plasma cell malignancy that occurs mainly in bone marrow. As MM cells proliferate slowly, it would… Expand
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Highly Cited
2001
Highly Cited
2001
The Bcl-2 family of proteins plays a central regulatory role in apoptosis. We have identified a novel, widely expressed Bcl-2… Expand
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Review
1999
Review
1999
Programmed cell death is an evolutionarily conserved cell death process that plays a major role during normal development and… Expand
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Highly Cited
1998
Highly Cited
1998
Malignant melanoma is a prime example of cancers that respond poorly to various treatment modalities including chemotherapy1. A… Expand
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Highly Cited
1998
Highly Cited
1998
An immunohistochemical study to determine the pattern of immunoreactivity for bcl-2 oncoprotein was performed in 380 spindle cell… Expand
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Highly Cited
1996
Highly Cited
1996
The Bcl-2 oncoprotein, which is expressed in a variety of human malignancies, blocks apoptosis induced by chemotherapeutic drugs… Expand
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Highly Cited
1995
Highly Cited
1995
Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking… Expand
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Highly Cited
1994
Highly Cited
1994
We studied the expression of bcl-2 oncoprotein in the gerbil hippocampus after transient ischemia. Immunostaining using… Expand
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Highly Cited
1993
Highly Cited
1993
A multidisciplinary approach was taken to investigate the intracellular locations of the 26-kDa integral membrane protein encoded… Expand
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