Proto-Oncogene Proteins c-bcl-2

Known as: c-bcl-2 Proteins, bcl-2 Proto-Oncogene Proteins, bcl 2 Proto Oncogene Proteins 
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
051019882017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The ubiquitin-proteasome system has recently emerged as a major target for drug development in cancer therapy. The proteasome… (More)
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Highly Cited
2008
Highly Cited
2008
Bcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as… (More)
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Highly Cited
2001
Highly Cited
2001
Defective cytochrome c release and the resulting loss of caspase-3 activation was recently shown to be essential for the… (More)
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2001
2001
The Bcl-2 family of proteins plays a central regulatory role in apoptosis. We have identified a novel, widely expressed Bcl-2… (More)
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2001
2001
The Bcl-2 oncoprotein is a potent inhibitor of apoptosis and is overexpressed in a variety of different malignancies. Bcl-2… (More)
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Highly Cited
2000
Highly Cited
2000
The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine… (More)
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1999
1999
Raf-1 activation and Bcl-2 hyperphosphorylation following treatment with paclitaxel (Taxol) or other microtubule-active drugs is… (More)
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Highly Cited
1997
Highly Cited
1997
The Bcl-2 oncoprotein is a key regulator of apoptosis and the Bag-1 protein interacts with Bcl-2 and cooperates with Bcl-2 to… (More)
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Highly Cited
1994
Highly Cited
1994
We studied the expression of bcl-2 oncoprotein in the gerbil hippocampus after transient ischemia. Immunostaining using… (More)
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Highly Cited
1988
Highly Cited
1988
Follicular lymphoma is the most common human B-cell malignancy in the United States and Western Europe1. Most of the tumours… (More)
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