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Human CD14 mediates recognition and phagocytosis of apoptotic cells
- A. Devitt, O. Moffatt, C. Raykundalia, J. D. Capra, D. Simmons, C. Gregory
- Biology, Medicine
- 2 April 1998
Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation. Here we show that the glycosylphosphatidylinositol-linked plasma-membrane… Expand
Differences in B cell growth phenotype reflect novel patterns of Epstein‐Barr virus latent gene expression in Burkitt's lymphoma cells.
Recently established Epstein‐Barr virus (EBV)‐positive Burkitt's lymphoma (BL) cell lines, carrying chromosomal translocations indicative of their malignant origin, have been monitored for their… Expand
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.
Cells undergoing apoptosis are efficiently located and engulfed by phagocytes. The mechanisms by which macrophages, the professional scavenging phagocytes of apoptotic cells, are attracted to sites… Expand
Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.
Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) biopsy cells and early passage BL cell lines have been reported as showing an unusual type of virus-cell interaction; at least two EBV latent… Expand
Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity.
A latent infection membrane protein (LMP) encoded by the Epstein-Barr virus (EBV) genome in latently infected, growth-transformed lymphocytes alters the phenotype of a human EBV-negative B-lymphoma… Expand
Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry.
- C. Dive, C. Gregory, D. Phipps, D. Evans, A. Milner, A. Wyllie
- Biology, Medicine
- Biochimica et biophysica acta
- 3 February 1992
Necrosis and apoptosis are two distinct modes of cell death which differ in morphology, mechanism and incidence. Membrane disruptants, respiratory poisons and hypoxia cause ATP depletion, metabolic… Expand
ALICE Technical Design Report of the Inner Tracking System (ITS)
Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues
Here we consider the impact of the physiological cell‐death programme on normal tissue homeostasis and on disease pathogenesis, with particular reference to evolution and progression of neoplasia. We… Expand
Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis
EPSTEiN-Barr virus (EBV), a human herpesvirus, establishes a persistent asymptomatic infection of the circulating B-lymphocyte pool1–3. The mechanism of virus persistence is not understood but, given… Expand
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.
Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor survival rates, with initial responses nearly invariably followed by rapid recurrence of therapy-resistant disease. Drug… Expand