Sonic hedgehog mediates the polarizing activity of the ZPA
- R. D. Riddle, Randy L. Johnson, E. Laufer, C. Tabin
- BiologyCell
- 31 December 1993
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
- A. Vortkamp, Kaechoong Lee, B. Lanske, G. Segre, H. Kronenberg, C. Tabin
- BiologyScience
- 2 August 1996
In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation.
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
- A. Yang, R. Schweitzer, F. McKeon
- BiologyNature
- 22 April 1999
It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a…
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
- E. Laufer, C. Nelson, Randy L. Johnson, B. Morgan, C. Tabin
- BiologyCell
- 16 December 1994
Biochemical evidence that Patched is the Hedgehog receptor
- V. Marigo, R. Davey, Y. Zuo, James M. Cunningham, C. Tabin
- BiologyNature
- 14 November 1996
Binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila4.
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.
- B. Harfe, Michael T. McManus, J. Mansfield, E. Hornstein, C. Tabin
- BiologyProceedings of the National Academy of Sciences…
- 2 August 2005
Using transgenes to drive Cre expression in discrete regions of the limb mesoderm, it is found that removal of Dicer results in the loss of processed miRNAs, and Dicer is required for the formation of normal mouse limbs.
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors.
- D. M. Bryant, Kimberly Johnson, J. Whited
- BiologyCell Reports
- 17 January 2017
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments.
- R. Schweitzer, J. Chyung, C. Tabin
- BiologyDevelopment
- 1 October 2001
Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and it is shown that early scleraxis expression marks the progenitor cell populations for these tissues.
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