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Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of skeletal elements, yet little is known about the molecular regulation of this process. A chicken homolog ofExpand
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Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in aExpand
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Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis.Expand
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Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments.
Little is known about the genesis and patterning of tendons and other connective tissues, mostly owing to the absence of early markers. We have found that Scleraxis, a bHLH transcription factor, is aExpand
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The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.
The RNaseIII-containing enzyme Dicer is believed to be required for the processing of most, if not all, microRNAs (miRNAs) and for processing long dsRNA into small interfering RNAs. Because theExpand
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Biochemical evidence that Patched is the Hedgehog receptor
THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the notochord that induces ventral cell fate in the neural tube andExpand
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Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling pathway mediating the transduction of the signal is still poorlyExpand
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Bmp4 and Morphological Variation of Beaks in Darwin's Finches
Darwin's finches are a classic example of species diversification by natural selection. Their impressive variation in beak morphology is associated with the exploitation of a variety of ecologicalExpand
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Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.
The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3a induces ectopicExpand
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Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
The scleraxis (Scx) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced a mutant null allele. Scx-/-Expand
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