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Gene Mutation

Known as: Gene Mutation Type, DNA Alteration, Gene Alteration 
The result of any gain, loss or alteration of the sequences comprising a gene, including all sequences transcribed into RNA.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Purpose The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well… Expand
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Highly Cited
2005
Highly Cited
2005
Most gastrointestinal stromal tumors (GIST) have an activating mutation in either KIT or PDGFRA. Imatinib is a selective tyrosine… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The course of chronic lymphocytic leukemia (CLL) is variable. In aggressive disease, the CLL cells usually express an… Expand
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Highly Cited
2004
Highly Cited
2004
CONTEXT Germline mutations of the genes encoding succinate dehydrogenase subunits B (SDHB) and D (SDHD) predispose to… Expand
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Highly Cited
2001
Highly Cited
2001
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with… Expand
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Highly Cited
1999
Highly Cited
1999
Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL… Expand
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Highly Cited
1999
Highly Cited
1999
Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM + B-chronic lymphocytic leukemia (B-CLL… Expand
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Highly Cited
1999
Highly Cited
1999
Internal tandem duplication of the FLT3 gene and point mutations of the N-RAS gene are the most frequent somatic mutations… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Idiopathic cerebral-vein thrombosis can cause serious neurologic disability. We evaluated risk factors for this… Expand
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Highly Cited
1990
Highly Cited
1990
BACKGROUND AND METHODS The plasma cholesteryl-ester transfer protein (CETP) catalyzes the transfer of cholesteryl esters from… Expand
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