Frameshift Mutation function

Known as: Out-of-Frame Mutations, frame-shift mutation, Reading Frame Shift Mutation 
A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby… (More)

Topic mentions per year

Topic mentions per year

1966-2018
010020030019662018

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Highly Cited
2010
Highly Cited
2010
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of… (More)
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Highly Cited
2009
Highly Cited
2009
Loss-of-function mutations in the FLG (filaggrin) gene cause the semidominant keratinizing disorder ichthyosis vulgaris and… (More)
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Highly Cited
2001
Highly Cited
2001
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of… (More)
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Highly Cited
2001
Highly Cited
2001
Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males 16–25 days after birth, and is… (More)
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Highly Cited
1999
Highly Cited
1999
EEC syndrome is an autosomal dominant disorder characterized by ectrodactyly, ectodermal dysplasia, and facial clefts. We have… (More)
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Highly Cited
1998
Highly Cited
1998
T he melanocortin-4 receptor (MC4R) is a G-protein coupled, seven-trans-membrane receptor which is highly expressed in the… (More)
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Highly Cited
1998
Highly Cited
1998
The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events… (More)
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Highly Cited
1997
Highly Cited
1997
The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific… (More)
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Highly Cited
1997
Highly Cited
1997
A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue… (More)
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Highly Cited
1991
Highly Cited
1991
Mutation rates are generally thought not to be influenced by selective forces. This doctrine rests on the results of certain… (More)
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