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Frameshift Mutation function

Known as: Out-of-Frame Mutations, frame-shift mutation, Reading Frame Shift Mutation 
A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby… Expand
National Institutes of Health

Related topics

Related topics

16 relations
CYP2C19*2 AlleleCYP2C19*3 AlleleCYP2C8*5 AlleleCYP2C9*6 Allele
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Broader (2)

Gene MutationMutation

Narrower (1)

Out-of-Frame Deletion

Papers overview

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Highly Cited
2013
Highly Cited
2013
Somatic mutations of calreticulin in myeloproliferative neoplasms.
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… Expand
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Highly Cited
2013
Highly Cited
2013
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
BACKGROUND Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular… Expand
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Highly Cited
2003
Highly Cited
2003
Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*
Nod2 activates the NF-κB pathway following intracellular stimulation by bacterial products. Recently, mutations inNod2 have been… Expand
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Highly Cited
2001
Highly Cited
2001
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions… Expand
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Highly Cited
2001
Highly Cited
2001
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males 16–25 days after birth, and is… Expand
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Highly Cited
1999
Highly Cited
1999
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Rett syndrome (RTT, MIM 312750) is a progressive neurodevelopmental disorder and one of the most common causes of mental… Expand
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Highly Cited
1997
Highly Cited
1997
Congenital leptin deficiency is associated with severe early-onset obesity in humans
The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific… Expand
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Highly Cited
1994
Highly Cited
1994
A cell cycle regulator potentially involved in genesis of many tumor types.
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases… Expand
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Highly Cited
1992
Highly Cited
1992
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous… Expand
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Highly Cited
1983
Highly Cited
1983
Revised methods for the Salmonella mutagenicity test.
The methods for detecting carcinogens and mutagens with the Salmonella mutagenicity test were described previously (Ames et al… Expand
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