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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
A dimer of the class II αβ heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation.
Structure of the human class I histocompatibility antigen, HLA-A2
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are…
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist, providing a universal mode of peptide binding, distinct from the strategy used by class I histocompatibility proteins.
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign…
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
Findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein.
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells*
It is demonstrated that activation of dendritic cells by TLR2 or TLR4 agonists, although it led to comparable activation of NF-κB and mitogen-activated protein kinase (MAPK) family members, resulted in striking differences in cytokine and chemokine gene transcription, suggesting that TLR 2 andTLR4 signaling is not equivalent.
Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
- L. Koopman, H. Kopcow, J. Strominger
- Biology, MedicineThe Journal of experimental medicine
- 20 October 2003
Natural killer cells constitute 50–90% of lymphocytes in human uterine decidua in early pregnancy and are compared with the CD56bright and CD56dim peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR.
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.
- J. Fingeroth, J. Weis, T. Tedder, J. Strominger, P. A. Biro, D. Fearon
- BiologyProceedings of the National Academy of Sciences…
- 1 July 1984
It is concluded that CR2 is the EBV receptor of human B lymphocytes, which recognize a Mr 145,000 B-lymphocyte membrane protein that is CR2.