• Publications
  • Influence
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from human B-cell membranes has been determined by X-ray crystallography and is similar to that of class I HLA.Expand
  • 2,204
  • 153
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist. Thirty-five per cent of the peptide surface is accessible to solvent and potentially available forExpand
  • 1,514
  • 65
Structure of the human class I histocompatibility antigen, HLA-A2
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that areExpand
  • 2,850
  • 59
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreignExpand
  • 2,252
  • 55
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surface of infected cells. However, class I downregulation potentially exposes the virus-infected cellExpand
  • 879
  • 51
  • PDF
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
Natural killer (NK) cells destroy virus-infected and tumour cells, apparently without the need for previous antigen stimulation. In part, target cells are recognized by their diminished expression ofExpand
  • 992
  • 44
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells*
Toll-like receptors (TLRs) mediate cell activation by various microbial products. Here, we demonstrate that activation of dendritic cells by TLR2 or TLR4 agonists, although it led to comparableExpand
  • 702
  • 41
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
Abstract Structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell response. Based on the structural requirements for both MHCExpand
  • 1,485
  • 37
Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2‐A and the activating receptor CD94/NKG2‐C to HLA‐E
The lytic function of human natural killer (NK) cells is markedly influenced by recognition of class I major histocompatibility complex (MHC) molecules, a process mediated by several types ofExpand
  • 334
  • 31
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen
The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a human class II histocompatibility complex molecule (HLA-DR1) has been determined by X-ray crystallography.Expand
  • 571
  • 30