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CYP2C19*2 Allele

Known as: CYP2C19, m1A, CYP2C19, c.681G>A, CYP2C19, m1 
Human CYP2C19*2 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type… Expand
National Institutes of Health

Related topics

Related topics

13 relations
10q24.1-q24.3Frameshift Mutation functionGuanosine to Adenosine Transition AbnormalityInactive - Biochemical Activity Level
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case-control study.
OBJECTIVE To investigate the contribution of CYP2C19 polymorphisms and body mass index (BMI) in the development of endometriosis… Expand
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2016
2016
Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive fungal infections.
Voriconazole (VCZ) use is limited by its narrow therapeutic range and significant interpatient variability in exposure. This… Expand
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Highly Cited
2012
Highly Cited
2012
Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial
BACKGROUND Prospective assessment of pharmacogenetic strategies has been limited by an inability to undertake bedside genetic… Expand
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Highly Cited
2010
Highly Cited
2010
CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study.
AIMS despite treatment with clopidogrel on top of aspirin, stent thrombosis (ST) still occurs being the most serious complication… Expand
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Highly Cited
2010
Highly Cited
2010
Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation.
INTRODUCTION The prodrug, clopidogrel, plays an important role in the prevention of thrombotic events in patients undergoing… Expand
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2010
2010
Assessment of CYP2C19 genetic polymorphisms in a Korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles.
BACKGROUND AND OBJECTIVE CYP2C19 is a drug-metabolizing enzyme showing various genetic polymorphisms that may cause marked… Expand
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Highly Cited
2009
Highly Cited
2009
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study
BACKGROUND Clopidogrel and low-dose aspirin have become the mainstay oral antiplatelet regimen to prevent recurrent ischaemic… Expand
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Highly Cited
2008
Highly Cited
2008
The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers
AimTo study the pharmacokinetic characteristics of voriconazole in healthy Chinese male volunteers in relation to cytochrome P450… Expand
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Highly Cited
1998
Highly Cited
1998
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.
The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This… Expand
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1996
1996
S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.
The polymorphic metabolism of S-mephenytoin and the distribution of two known deleterious mutant CYP2C19 alleles was determined… Expand
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