CYP2C19*2 Allele

Known as: CYP2C19, m1A, CYP2C19, c.681G>A, CYP2C19, m1 
Human CYP2C19*2 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
020406019962018

Papers overview

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Highly Cited
2011
Highly Cited
2011
CONTEXT Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVES The aim of this study was to assess the association between the loss-of-function cytochrome P450 2C19 (CYP2C19)*2… (More)
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2010
2010
AIMS despite treatment with clopidogrel on top of aspirin, stent thrombosis (ST) still occurs being the most serious complication… (More)
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Highly Cited
2009
Highly Cited
2009
CONTEXT Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Clopidogrel and low-dose aspirin have become the mainstay oral antiplatelet regimen to prevent recurrent ischaemic… (More)
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Highly Cited
2008
Highly Cited
2008
Recently, a novel allelic variant of cytochrome P450 2C19 encoding ultrarapid enzyme activity was described (denoted CYP2C19*17… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y(12) adenosine… (More)
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Highly Cited
2006
Highly Cited
2006
The capacity of clopidogrel to inhibit ADP-induced platelet aggregation shows wide intersubject variability. To determine whether… (More)
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Highly Cited
2004
Highly Cited
2004
The polymorphic cytochrome P450 isoenzymes (CYPs) 2C9, 2C19 and 2D6 metabolise many important drugs, as well as other xenobiotics… (More)
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2001
2001
Phenytoin, an anticonvulsant, exhibits nonlinear pharmacokinetics with large interindividual differences. Because of its small… (More)
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