FAQ

CYP2C19*2 Allele

Known as: CYP2C19, m1A, CYP2C19, c.681G>A, CYP2C19, m1 
Human CYP2C19*2 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
020406019962018

Related topics

Related topics

11 relations
10q24.1-q24.3Frameshift Mutation functionIron ChelationMetabolic Detoxication, Drug
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CYP2C19*2 Allele
Oxidation-Reduction
Metabolic Detoxication, Drug
drug metabolism
Metabolism
Frameshift Mutation function

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease.
CONTEXT Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance… (More)
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Highly Cited
2010
Highly Cited
2010
Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis.
OBJECTIVES The aim of this study was to assess the association between the loss-of-function cytochrome P450 2C19 (CYP2C19)*2… (More)
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2010
2010
CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study.
AIMS despite treatment with clopidogrel on top of aspirin, stent thrombosis (ST) still occurs being the most serious complication… (More)
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Highly Cited
2009
Highly Cited
2009
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
CONTEXT Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous… (More)
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Highly Cited
2009
Highly Cited
2009
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.
BACKGROUND Clopidogrel and low-dose aspirin have become the mainstay oral antiplatelet regimen to prevent recurrent ischaemic… (More)
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Highly Cited
2008
Highly Cited
2008
Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients.
Recently, a novel allelic variant of cytochrome P450 2C19 encoding ultrarapid enzyme activity was described (denoted CYP2C19*17… (More)
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Highly Cited
2007
Highly Cited
2007
Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.
BACKGROUND Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y(12) adenosine… (More)
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Highly Cited
2006
Highly Cited
2006
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.
The capacity of clopidogrel to inhibit ADP-induced platelet aggregation shows wide intersubject variability. To determine whether… (More)
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Highly Cited
2004
Highly Cited
2004
Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.
The polymorphic cytochrome P450 isoenzymes (CYPs) 2C9, 2C19 and 2D6 metabolise many important drugs, as well as other xenobiotics… (More)
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2001
2001
The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels
Phenytoin, an anticonvulsant, exhibits nonlinear pharmacokinetics with large interindividual differences. Because of its small… (More)
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