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CYP2C19*2 Allele
Known as:
CYP2C19, m1A
, CYP2C19, c.681G>A
, CYP2C19, m1
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Human CYP2C19*2 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type…
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National Institutes of Health
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Related topics
Related topics
13 relations
10q24.1-q24.3
Frameshift Mutation function
Guanosine to Adenosine Transition Abnormality
Inactive - Biochemical Activity Level
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case-control study.
J. V. Cardoso
,
M. Abrão
,
+4 authors
J. Perini
European journal of obstetrics, gynecology, and…
2017
Corpus ID: 23734590
Highly Cited
2016
Highly Cited
2016
Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive fungal infections.
F. Lamoureux
,
T. Duflot
,
+8 authors
C. Thuillez
International journal of antimicrobial agents
2016
Corpus ID: 37237656
Highly Cited
2012
Highly Cited
2012
Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial
Jason D. Roberts
,
G. Wells
,
+11 authors
D. So
The Lancet
2012
Corpus ID: 25439653
Highly Cited
2011
Highly Cited
2011
High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (Clopidogrel and Response Variability Investigation Study 2).
J. Collet
,
J. Hulot
,
+12 authors
G. Montalescot
JACC. Cardiovascular interventions
2011
Corpus ID: 25992178
Highly Cited
2010
Highly Cited
2010
CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study.
A. Harmsze
,
J. V. van Werkum
,
+9 authors
V. Deneer
European heart journal
2010
Corpus ID: 5395716
AIMS despite treatment with clopidogrel on top of aspirin, stent thrombosis (ST) still occurs being the most serious complication…
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Highly Cited
2010
Highly Cited
2010
Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation
A. Harmsze
,
J. V. van Werkum
,
+8 authors
V. Deneer
Pharmacogenetics and genomics
2010
Corpus ID: 205602725
Introduction The prodrug clopidogrel plays an important role in the prevention of thrombotic events in patients undergoing…
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Highly Cited
2009
Highly Cited
2009
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study
J. Collet
,
J. Hulot
,
+10 authors
G. Montalescot
The Lancet
2009
Corpus ID: 22405890
Highly Cited
2008
Highly Cited
2008
The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers
Guo Wang
,
H. Lei
,
+7 authors
Honghao Zhou
European Journal of Clinical Pharmacology
2008
Corpus ID: 8636379
AimTo study the pharmacokinetic characteristics of voriconazole in healthy Chinese male volunteers in relation to cytochrome P450…
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Highly Cited
1998
Highly Cited
1998
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.
R. J. Ferguson
,
S. D. de Morais
,
+8 authors
J. Goldstein
The Journal of pharmacology and experimental…
1998
Corpus ID: 7356664
The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This…
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Highly Cited
1996
Highly Cited
1996
S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.
I. Persson
,
E. Aklillu
,
F. Rodrigues
,
L. Bertilsson
,
M. Ingelman-Sundberg
Pharmacogenetics
1996
Corpus ID: 21907109
The polymorphic metabolism of S-mephenytoin and the distribution of two known deleterious mutant CYP2C19 alleles was determined…
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