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A consensus on criteria for cure of acromegaly.
TLDR
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines. Expand
A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo.
TLDR
Life-long exposure to the mutated allele may be accompanied by an increased BMI and a lowered BMD in the lumbar spine but does not affect blood pressure, and individuals carrying this polymorphism had a higher sensitivity to exogenously administered glucocorticoids. Expand
The pathophysiological consequences of somatostatin receptor internalization and resistance.
TLDR
The pathophysiological role of somatostatin receptor subtypes in determining the efficacy of treatment of patients with somatstatin receptor-positive tumors using som atostatin analogs is covered, as well as the preclinical and clinical consequences of agonist-induced receptor internalization for somatOSTatin receptors-targeted radio- and chemotherapy. Expand
Evaluation of a method to measure long term cortisol levels
TLDR
Hair cortisol was positively correlated with WHR, suggesting that hair cortisol reflects cortisol exposure at tissue level, which was also supported by elevatedhair cortisol levels in hypercortisolemic patients and concordance between hair cortisol levels and clinical disease course. Expand
Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition.
TLDR
Polymorphisms in the GR gene may contribute considerably to the observed variability in GC sensitivity and changes in body composition and metabolic parameters, as a result of they are associated with several differences in body compositions and metabolic factors. Expand
Corticosteroid therapy in severe illness.
TLDR
Standard therapy for the latter patients consists of the administration of high doses of corticosteroids during any severe illness and perioperatively, and replacement doses or high doses in patients with severe illness, especially those with multiorgan-system diseases. Expand
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction.
TLDR
This study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction. Expand
Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron-specific enolase and the alpha-subunit of glycoprotein hormones.
TLDR
Although its specificity cannot compete with that of the specific hormonal secretion products of most neuro endocrine tumors, it can have useful clinical applications in subjects with neuroendocrine tumors for whom either no marker is available or the marker is inconvenient for routine clinical use. Expand
The role of somatostatin and its analogs in the diagnosis and treatment of tumors.
TLDR
Experimental studies show that chronic administration of somatostatin analogs causes growth inhibition of a number of (transplantable) tumors in animals, including chondrosarcomas, pancreatic, prostatic, breast, and pituitary cancers. Expand
Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression
TLDR
Findings support the notion that variants of the GR gene might play a role in the pathophysiology of a major depression and can contribute to the variability of antidepressant response. Expand
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