A consensus on criteria for cure of acromegaly.
- A. Giustina, P. Chanson, S. Melmed
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 July 2010
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines.
A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo.
- N. Huizenga, J. Koper, S. Lamberts
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
Life-long exposure to the mutated allele may be accompanied by an increased BMI and a lowered BMD in the lumbar spine but does not affect blood pressure, and individuals carrying this polymorphism had a higher sensitivity to exogenously administered glucocorticoids.
The pathophysiological consequences of somatostatin receptor internalization and resistance.
The pathophysiological role of somatostatin receptor subtypes in determining the efficacy of treatment of patients with somatstatin receptor-positive tumors using som atostatin analogs is covered, as well as the preclinical and clinical consequences of agonist-induced receptor internalization for somatOSTatin receptors-targeted radio- and chemotherapy.
Evaluation of a method to measure long term cortisol levels
Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition.
Polymorphisms in the GR gene may contribute considerably to the observed variability in GC sensitivity and changes in body composition and metabolic parameters, as a result of they are associated with several differences in body compositions and metabolic factors.
Corticosteroid therapy in severe illness.
Standard therapy for the latter patients consists of the administration of high doses of corticosteroids during any severe illness and perioperatively, and replacement doses or high doses in patients with severe illness, especially those with multiorgan-system diseases.
Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron-specific enolase and the alpha-subunit of glycoprotein hormones.
- F. Nobels, D. Kwekkeboom, S. Lamberts
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 August 1997
Although its specificity cannot compete with that of the specific hormonal secretion products of most neuro endocrine tumors, it can have useful clinical applications in subjects with neuroendocrine tumors for whom either no marker is available or the marker is inconvenient for routine clinical use.
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction.
This study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction.
The role of somatostatin and its analogs in the diagnosis and treatment of tumors.
Experimental studies show that chronic administration of somatostatin analogs causes growth inhibition of a number of (transplantable) tumors in animals, including chondrosarcomas, pancreatic, prostatic, breast, and pituitary cancers.
Expert consensus document: A consensus on the medical treatment of acromegaly
This document represents the conclusions of the workshop consensus and considered treatment goals covering biochemical, clinical and tumour volume outcomes, and the place in guidelines of somatostatin receptor ligands, growth hormone receptor antagonists and dopamine agonists.