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Chromosome Aberrations

Known as: Abnormalities, Chromosomal, Aberrations, Chromosomal, Aberration, Cytogenetic 
An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or… 
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (20)

47, XYY syndromeAneuploidyAutosomal deletion syndromesAutosome Abnormalities
Chromosome 13q deletion syndromeChromosomesComplete trisomy 18 syndromeCongenital chromosomal disease

Broader (5)

Congenital DisordersFetal DiseasesGene MutationHereditary Diseases

Papers overview

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Highly Cited
2000
Highly Cited
2000
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.
The eukaryotic cell cycle is overseen by regulatory mechanisms, termed checkpoints, that respond to DNA damage, mitotic spindle… 
Highly Cited
1995
Highly Cited
1995
Cloning and characterization of murine p16INK4a and p15INK4b genes.
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6… 
Highly Cited
1995
Highly Cited
1995
TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.
We have previously shown that the LAZ3/BCL6 gene encoding a potential transcription factor, is disrupted in B-diffuse large cell… 
Highly Cited
1994
Highly Cited
1994
Potential markers of prostate cancer aggressiveness detected by fluorescence in situ hybridization in needle biopsies.
Fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 11, and 12 was used to evaluate… 
Highly Cited
1994
Highly Cited
1994
Aneuploidy and aneusomy of chromosome 7 detected by fluorescence in situ hybridization are markers of poor prognosis in prostate cancer.
Fluorescence in situ hybridization is a new methodology which can be used to detect cytogenetic anomalies within interphase tumor… 
Highly Cited
1987
Highly Cited
1987
Cytogenetic studies on 519 consecutive de novo acute nonlymphocytic leukemias.
Review
1986
Review
1986
Activation of cellular oncogenes in hemopoietic cells by chromosome translocation.
Highly Cited
1984
Highly Cited
1984
Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma.
Highly Cited
1984
Highly Cited
1984
Recurrent chromosomal defects are found in most patients with acute nonlymphocytic leukemia.
Highly Cited
1976
Highly Cited
1976
Clonal lines of teratocarcinoma cells in vitro: Differentiation and cytogenetic characteristics
Clonal lines of embryonal carcinoma cells have been established in culture from four independently‐derived transplantable… 
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