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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalianExpand
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Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells
Dissection of the subependyma from the lateral ventricle of the adult mouse forebrain is necessary and sufficient for the in vitro formation of clonally derived spheres of cells that exhibit stemExpand
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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.
It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in thisExpand
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Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
The inhibitors of apoptosis (IAPs) suppress apoptosis through the inhibition of the caspase cascade and thus are key proteins in the control of cell death. Here we have isolated the proteinExpand
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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has beenExpand
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AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
OBJECTIVE Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and physical endurance andExpand
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A local mechanism mediates NAD-dependent protection of axon degeneration
Axon degeneration occurs frequently in neurodegenerative diseases and peripheral neuropathies. Important insight into the mechanisms of axon degeneration arose from findings that the degeneration ofExpand
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Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells
Murine embryonal carcinoma cells can differentiate into a varied spectrum of cell types. We observed the abundant and precocious development of neuronlike cells when embryonal carcinoma cells ofExpand
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Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line
Pluripotent marine embryonal carcinoma cells can differentiate in culture into many tissue types similar to those normally found in early embryos1 and may be useful in investigating someExpand
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SIRT1 Regulates HIV Transcription via Tat Deacetylation
The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated byExpand
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