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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability… Expand The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent… Expand An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells. Boveri proposed nearly 100 years ago that… Expand Aneuploidy is one of the most obvious differences between normal and cancer cells. However, there remains debate over how… Expand Abnormal chromosome content — also known as aneuploidy — is the most common characteristic of human solid tumours. It has… Expand Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well… Expand Aneuploidy (trisomy or monosomy) is the most commonly identified chromosome abnormality in humans, occurring in at least 5% of… Expand Numeric aberrations in chromosomes, referred to as aneuploidy, is commonly observed in human cancer. Whether aneuploidy is a… Expand The centrosomes are thought to maintain genomic stability through the establishment of bipolar spindles during cell division… Expand In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization… Expand