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Proposals for the classification of the myelodysplastic syndromes
TLDR
It is now proposed that over 30% of bone marrow blasts will suffice for the diagnosis of acute myeloid leukaemia (AML) in any of its forms (M1‐M6) and recognition of the new category, RAEB in transformation, may throw light on the pathogenesis of AML.
Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group
Summary. A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical
Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group.
Excerpt The first proposals for the morphologic classification of the acute leukemias by the French-American-British (FAB) group (1) were put forward in the hope that they might serve as a basis fo...
World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.
TLDR
The World Health Organization classification of hematologic malignancies, including lymphoid, myeloid, histiocytic, and mast cell neoplasms, has produced a new and exciting degree of cooperation and communication between oncologists and pathologists from around the world, which should facilitate progress in the understanding and treatment ofhematologicmalignancies.
Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML‐MO)
TLDR
A form of acute myeloid leukaemia (AML), designated AML‐MO, with minimalMyeloid differentiation, not included previously in the FAB classification is described and its clinical and biological significance is not yet apparent.
Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group.
TLDR
In patients with increased reticulin, the bone marrow sample may be difficult to obtain and the counts done on the marrow films may be misleading, so the diagnosis of M7 should be based on excellent bone marrow biopsy sections that show an excess of blasts and, at times, increased numbers of maturing megakaryocytes.
The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia: Proposals by the French ‐ American ‐ British
TLDR
A statstical model is developed that confirms that CGL, aCML and CMML can be distinguished from each other with reasonable success employing five quantitative parameters and one qualitative parameter.
The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November,
TLDR
The experience of developing the WHO Classification has produced a new and exciting degree of cooperation and communication between oncologists and pathologists from around the world, which should facilitate progress in the understanding and treatment of hematologic malignancies.
Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group.
Peripheral blood, bone marrow films, and bone marrow biopsy specimens from 110 patients, well characterised by clinical and laboratory studies, including electron microscopy, were reviewed, to
Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français
TLDR
This study highlights the importance of combining morphologic, cytogenetic, and molecular analyses for optimal management of APL patients and better understanding of the pathogenesis of the disease.
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