Skip to search formSkip to main contentSkip to account menu

DNA Damage

Known as: Damages, DNA, DNA Injury, Damage, DNA 
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA… 
National Institutes of Health

Related topics

Related topics

16 relations
Adverse effectsAdverse reaction to drugChromosome StructuresComet Assay

Broader (1)

Gene Mutation

Narrower (1)

Genotoxic Stress

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA damage, interest in the changes to… 
Highly Cited
2005
Highly Cited
2005
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal… 
Highly Cited
2002
Highly Cited
2002
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage… 
Highly Cited
2002
Highly Cited
2002
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR… 
Highly Cited
2000
Highly Cited
2000
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Chk2 is a protein kinase that is activated in response to DNA damage and may regulate cell cycle arrest. We generated Chk2… 
Highly Cited
1999
Highly Cited
1999
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts… 
Highly Cited
1997
Highly Cited
1997
Wavelength dependence of oxidative DNA damage induced by UV and visible light.
DNA damage induced by UV radiation and visible light (290-500 nm) in AS52 Chinese hamster cells was analysed by an alkaline… 
Review
1994
Review
1994
Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.
General correlations are found between the detailed spatial and temporal nature of the initial physical features of radiation… 
Highly Cited
1990
Highly Cited
1990
Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the “Comet” Assay
A method for measuring DNA damage to individual cells, based on the technique of microelectrophoresis, was described by Ostling… 
Highly Cited
1988
Highly Cited
1988
The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.
Cell division is arrested in many organisms in response to DNA damage. Examinations of the genetic basis for this response in the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)