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DNA Damage

Known as: Damages, DNA, DNA Injury, Damage, DNA 
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA… 
National Institutes of Health

Related topics

Related topics

16 relations
Adverse effectsAdverse reaction to drugChromosome StructuresComet Assay

Broader (1)

Gene Mutation

Narrower (1)

Genotoxic Stress

Papers overview

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Highly Cited
1995
Highly Cited
1995
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.
When [14C]tamoxifen was incubated with horseradish peroxidase and H2O2, two major metabolites, separated and identified by HPLC… 
Highly Cited
1987
Highly Cited
1987
Repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage by ABC excinuclease
Escherichia coli has several overlapping DNA repair pathways which act in concert to eliminate the DNA damage caused by a diverse… 
Highly Cited
1986
Highly Cited
1986
Identification of DNA damage as a result of exposure of rats to diesel engine exhaust.
Owing to the concern regarding genotoxic agents which may be present in diesel engine emissions we have studied the effect, with… 
1986
1986
The effect of macrophage development on the release of reactive oxygen intermediates and lipid oxidation products, and their ability to induce oxidative DNA damage in mammalian cells.
Inflammation and the release of potentially damaging substances, such as reactive oxygen intermediates (ROI) and lipid oxidation… 
Highly Cited
1985
Highly Cited
1985
Activation of neocarzinostatin chromophore and formation of nascent DNA damage do not require molecular oxygen.
Thiol-activated neocarzinostatin chromophore abstracts tritium from the 5', but not from the 1' or 2' positions of deoxyribose in… 
1984
1984
Relationship between a chromatin anomaly in ataxia-telangiectasia cells and enhanced sensitivity to DNA damage.
The cellular basis for the enhanced sensitivity to ionising radiation and some DNA damaging chemicals in ataxia-telangiectasia… 
1982
1982
DNA damage in liver, kidney, bone marrow, and spleen of rats and mice treated with commercial and purified aniline as determined by alkaline elution assay and sister chromatid exchange induction.
Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in… 
1980
1980
DNA synthesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.
The effects of N-methyl- and N-ethyl-N'-nitro-N-nitrosoguanidines and methyl and ethyl methanesulfonates on DNA synthesis in C3H… 
1979
1979
Topographical delimitation of Oporinia-damages: experimental evidence of the effect of winter temperature.
1979
1979
Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.
Mutation to 8-azaguanine resistance in Chinese hamster cells and cytotoxicity and production and repair of alkalilabile lesions…