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NA damage has emerged as a major culprit in cancer and many diseases related to aging. The stability of the genome is supported… Expand Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic… Expand The function of the ATR (ataxia-telangiectasia mutated– and Rad3-related)–ATRIP (ATR-interacting protein) protein kinase complex… Expand A major development of carcinogenesis research in the past 20 years has been the discovery of significant levels of DNA damage… Expand BACKGROUND
The response of eukaryotic cells to double-strand breaks in genomic DNA includes the sequestration of many factors… Expand After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle. It is shown here that this… Expand DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms. Here we show that phosphorylation… Expand The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could… Expand Human lymphocytes were either exposed to X-irradiation (25 to 200 rads) or treated with H2O2 (9.1 to 291 microM) at 4 degrees C… Expand A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton… Expand