DNA Damage

Known as: Damages, DNA, DNA Injury, Damage, DNA 
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can… (More)
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Review
2017
Review
2017
Many surveillance and repair mechanisms exist to maintain the integrity of our genome. All of the pathways described to date are… (More)
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Highly Cited
2003
Highly Cited
2003
The function of the ATR (ataxia-telangiectasia mutated- and Rad3-related)-ATRIP (ATR-interacting protein) protein kinase complex… (More)
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Highly Cited
2003
Highly Cited
2003
We report cytologic and genetic data indicating that telomere dysfunction induces a DNA damage response in mammalian cells… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The response of eukaryotic cells to double-strand breaks in genomic DNA includes the sequestration of many factors… (More)
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Highly Cited
1998
Highly Cited
1998
After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle. It is shown here that this… (More)
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Highly Cited
1997
Highly Cited
1997
DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms. Here we show that phosphorylation… (More)
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Highly Cited
1997
Highly Cited
1997
A significant amount of reactive oxygen species (ROS) is generated during mitochondrial oxidative phosphorylation. Several… (More)
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Highly Cited
1991
Highly Cited
1991
The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could… (More)
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Highly Cited
1988
Highly Cited
1988
Human lymphocytes were either exposed to X-irradiation (25 to 200 rads) or treated with H2O2 (9.1 to 291 microM) at 4 degrees C… (More)
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