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DNA Damage

Known as: Damages, DNA, DNA Injury, Damage, DNA 
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA… 
National Institutes of Health

Related topics

Related topics

16 relations
Adverse effectsAdverse reaction to drugChromosome StructuresComet Assay

Broader (1)

Gene Mutation

Narrower (1)

Genotoxic Stress

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
Coenzyme A (CoA) is an essential cofactor required for cellular metabolism. CoA is synthesized de novo from pantothenate (vitamin… 
Highly Cited
2009
Highly Cited
2009
Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells.
Highly Cited
2007
Highly Cited
2007
DNA damage induces Chk1‐dependent centrosome amplification
Centrosomal abnormalities are frequently observed in cancers and in cells with defective DNA repair. Here, we used light and… 
Review
2006
Review
2006
Interactions between DNA viruses, ND10 and the DNA damage response
ND10 are small nuclear substructures that are defined by the presence the promyelocytic leukaemia protein PML. Many other… 
Highly Cited
1999
Highly Cited
1999
Ataxia Telangiectasia-mutated Gene Product Inhibits DNA Damage-induced Apoptosis via Ceramide Synthase*
DNA double-stranded breaks (dsb) activate surveillance systems that identify DNA damage and either initiate repair or signal cell… 
Highly Cited
1999
Highly Cited
1999
ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2.
The survival of type 2 alveolar epithelial cells (AEC2) in the lung after hyperoxic injury is regulated by signals from the… 
Highly Cited
1997
Highly Cited
1997
Contribution of genetic and nutritional factors to DNA damage in heavy smokers.
Prior epidemiological evidence suggests that genes controlling the metabolism of carcinogens and antioxidant/nutritional status… 
Highly Cited
1996
Highly Cited
1996
Damage, Repair, and Mutagenesis in Nuclear Genes after Mouse Forebrain Ischemia–Reperfusion
To determine whether oxidative stress after cerebral ischemia–reperfusion affects genetic stability in the brain, we studied… 
Highly Cited
1990
Highly Cited
1990
Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage
In eucaryotic cells, incompletely replicated or damaged chromosomes induce cell cycle arrest in G2 before mitosis, and in the… 
Highly Cited
1982
Highly Cited
1982
Fluorometric quantitation of single-stranded DNA: a method applicable to the technique of alkaline elution.
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