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Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division.
A line of C3H mouse embryo cells sensitive to postconfluence inhibition of cell division was used for a variety of quantitative and qualitative studies of chemical oncogenesis in culture and two of the three types of foci gave rise to fibrosarcomas. Expand
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative. Expand
Fluorinated pyrimidines and their nucleosides.
This chapter will deal primarily with a review of the major pharmacological and biochemical effects of these compounds and will focus only on key references that are germane to the topics being described. Expand
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
The levels of dUMP found after exposure to 5-FUra are sufficient to severely retard inhibition of TMP synthetase by FdUMP. Expand
Fluorinated pyrimidines.
  • C. Heidelberger
  • Biology, Medicine
  • Progress in nucleic acid research and molecular…
  • 1 November 1963
Hydrolysis revealed that the compound was incorporated into the DNA as such, the replacement of thymine amounting to up to 10%. Expand
Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.
At all times after intraperitoneal injection of 5-fluorouracil into mice bearing Sarcoma 180, aHigher specific activity was found in the tumor than in all other tissues investigated, and in the cancer patient the tumor biopsy had a higher specific activity than surrounding skin, muscle, fat, and a liver biopsy. Expand
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
Levels of free TS in the tumor after 5-FUra treatment are predictive of chemotherapeutic response in these murine models of human colonic adenocarcinoma, and could not be explained by the small differences among the tumors in total perchloric acid-soluble metabolites of 5-UFra or drug incorporation into RNA. Expand
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.
Thymidylate synthetase from Ehrlich ascites carcinomna cells has been assayed by a spectrophotometric method, and several new properties of this enzyme have been discovered. Thymidylate produces aExpand
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine.
There is no correlation between the extent of catabolism of F3TdR and its clinical efficacy and the 1st- and 2nd-hr urines of eight pediatric patients were studied, and the children metabolized the drug less rapidly than did adults. Expand