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Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells.
Chronic exposure to low levels of environmentally derived arsenite are associated with vascular diseases, such as arteriosclerosis. However, the cellular and molecular mechanisms for vascular diseaseExpand
Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells 1
Chromium(III) complexes currently being sold as dietary supplements were tested for their ability to cause chromosomal aberrations in Chinese hamster ovary cells. Complexes were tested in soluble andExpand
Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicals.
Reaction of potassium dichromate with sodium ascorbate was studied by EPR spectroscopy at room temperature, in 0.10 M N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid] (HEPES), phosphate,Expand
Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism.
NF-kappa B binding to DNA in the presence of thiol-reactive metals has been explored in vitro. Gel mobility shift assays using total nuclear extracts isolated from tumor necrosis factor alpha-treatedExpand
Metabolism of the carcinogen chromate by cellular constituents
The redox chemistry of chromium(VI) is discussed with respect to the cellular metabolism of the carcinogen chromate in vivo. Possible sites for cellular reduction of chromium(VI) to chromium(III) areExpand
Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage.
The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI)Expand
A prediction of chromium(III) accumulation in humans from chromium dietary supplements
It has been proposed that 90% of American's diets are deficient in the trace essential mineral chromium. Several chromium(III) dietary supplements are currently available to alleviate thisExpand
The interaction of chromium with nucleic acids.
Native and denatured calf thymus DNA, and homopolyribonucleotides were compared with respect to chromium and protein binding after an in vitro incubation with rat liver microsomes, NADPH, andExpand
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.
Hepatic 5-aminolevulinate (ALA) synthase, the first and rate-limiting enzyme in the heme biosynthetic pathway, is known to be feedback repressed by the end product of the pathway, heme. WeExpand