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Genotoxic Stress

Known as: Genotoxic Stresses, Stress, Genotoxic, Stresses, Genotoxic 
Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage. Genotoxic stress elicits biochemical responses… 
National Institutes of Health

Related topics

Related topics

4 relations
Cellular Stress ResponseChromosome StructuresDNA Repair

Broader (1)

DNA Damage

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage.
Review
2008
Review
2008
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.
Highly Cited
2007
Highly Cited
2007
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges
Background DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding… 
2007
2007
Induction of Cdc25B regulates cell cycle resumption after genotoxic stress.
Cdc25 phosphatases propel cell cycle progression by activating cyclin-dependent kinases (Cdk). DNA damage is generally thought to… 
2004
2004
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.
Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for… 
Highly Cited
2002
Highly Cited
2002
Genotoxic Stress-Induced Activation of Plk3 is Partly Mediated by Chk2
Polo-like kinase 3 (Plk3, alternatively termed Prk) is involved in the regulation of DNA damage checkpoint as well as in M-phase… 
Highly Cited
2001
Highly Cited
2001
Ataxia Telangiectasia Mutated-Dependent Apoptosis after Genotoxic Stress in the Developing Nervous System Is Determined by Cellular Differentiation Status
Ataxia-telangiectasia (A-T) is a neurodegenerative syndrome resulting from dysfunction of ATM (ataxia telangiectasia mutated… 
Highly Cited
2000
Highly Cited
2000
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.
The eukaryotic cell cycle is overseen by regulatory mechanisms, termed checkpoints, that respond to DNA damage, mitotic spindle… 
1999
1999
Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress
In order to identify the alternative pathways which may substitute for the p53 function during embryogenesis, we have focused our… 
1997
1997
Alkaline single cell gel electrophoresis of DNA fragments in biomonitoring for genotoxicity: an introductory study on healthy human volunteers
Abstract Alkaline single cell gel electrophoresis (also known as the ‘comet assay’) is a rapid method for detecting DNA strand… 
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