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DNA Repair

Known as: DNA Damage Repair, Deoxyribonucleic acid repair, Unscheduled DNA Synthesis 
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair… 
National Institutes of Health

Related topics

Related topics

50 relations
APEX1 protein, humanAPEX2 geneAPITD1 geneATR gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR associated protein 9 (Cas9)-based therapeutics… 
Review
2014
Review
2014
Sources of DNA double-strand breaks and models of recombinational DNA repair.
DNA is subject to many endogenous and exogenous insults that impair DNA replication and proper chromosome segregation. DNA double… 
Review
2012
Review
2012
DNA repair dysregulation from cancer driver to therapeutic target
Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the DNA damage response (DDR), is… 
Highly Cited
2007
Highly Cited
2007
DNA repair is limiting for haematopoietic stem cells during ageing
Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of ageing. Here we… 
Review
2005
Review
2005
p53: traffic cop at the crossroads of DNA repair and recombination
p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in… 
Review
2004
Review
2004
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
Class-switch recombination (CSR) of immunoglobulin heavy chains is the genetic process by which a B cell switches from the… 
Highly Cited
1995
Highly Cited
1995
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
The degradation of many proteins involves the sequential ligation of ubiquitin molecules to the substrate to form a… 
Highly Cited
1994
Highly Cited
1994
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
IN mammalian cells, DNA damage increases the levels of the nuclear tumour-suppressor p53, resulting in elevated synthesis of p21… 
Highly Cited
1994
Highly Cited
1994
An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III
XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the… 
Review
1975
Review
1975
SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis.
A hypothesis was proposed several years ago that Escherichia coli posses an inducible DNA repair system ("SOS repair") which is… 
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