K. Nasmyth

Publications339
h-index138
Citations56,125
Highly Influential Citations3,706
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Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids
TLDR
Three chromosmal proteins that prevent premature separation of sister chromatids in yeast are described, two of which are members of the SMC family, which are putative ATPases with coiled-coil domains. Expand
Molecular architecture of SMC proteins and the yeast cohesin complex.
TLDR
The crystal structure of a bacterial SMC "hinge" region along with EM studies and biochemical experiments on yeast Smc1 and Smc3 proteins show that SMC protamers fold up individually into rod-shaped molecules. Expand
A Central Role for Cohesins in Sister Chromatid Cohesion, Formation of Axial Elements, and Recombination during Yeast Meiosis
TLDR
It is shown that Smc3p and a meiotic version of Scc1p called Rec8p are required for cohesion between sister chromatids, for formation of axial elements, for reciprocal recombination, and for preventing hyperresection of double-strand breaks during meiosis. Expand
The B-type cyclin kinase inhibitor p40 SIC1 controls the G1 to S transition in S. cerevisiae
TLDR
It is shown that DNA replication also requires activation of Cdc28 by B-type (Clb) cyclins, and proteolysis of a cyclin-specific inhibitor of CDC28 is an essential aspect of the G1 to S phase transition. Expand
Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections
TLDR
IPL1 function in cells that cannot replicate their chromosomes but nevertheless duplicate their spindle pole bodies (SPBs) is investigated and the possibility that Ipl1-Sli15 facilitates bi-orientation by promoting turnover of kinetochore-SPB connections until traction of sister Kinetochores toward opposite spindle poles creates tension in the surrounding chromatin is raised. Expand
Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.
TLDR
This and a previous study have identified six proteins essential for establishing or maintaining sister chromatid cohesion, four of which are subunits of a 'Cohesin' complex that binds chromosomes from late G1 until the onset of anaphase. Expand
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.
TLDR
It is shown that Scc2p forms a complex with a novel protein, Scc4p, which is also necessary for sister cohesion, suggesting that a major role for the SCC2p/SCC4p complex is to facilitate the loading of cohesin complexes onto chromosomes. Expand
Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex.
TLDR
The mutual inhibition between APC and CDKs explains how cells suppress mitotic CDK activity during G1 and then establish a period with elevated kinase activity from S phase until anaphase. Expand
Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
TLDR
It is shown that Esp1 causes the dissociation of Scc1 from chromosomes by stimulating its cleavage by proteolysis, and a mutant SCC1 is described that is resistant to Esp1-dependent cleavage and which blocks both sister-chromatid separation and the dissociations from chromosomes. Expand
The Polo‐like kinase Cdc5p and the WD‐repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
TLDR
It is shown that both Cdc5p and Cdc20p are unstable proteins whose proteolysis is regulated by the APC, both proteins accumulate during late G2/M phase and disappear at a late stage of anaphase. Expand
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