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ATR gene

Known as: SCKL1, ATAXIA-TELANGIECTASIA AND RAD3-RELATED, MEC1 
This gene is involved in cell cycle checkpoints and DNA recombination.
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular… Expand
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Highly Cited
2007
Highly Cited
2007
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and… Expand
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Highly Cited
2007
Highly Cited
2007
Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR… Expand
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Highly Cited
2005
Highly Cited
2005
Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also called KLRK1) expressed by natural… Expand
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Highly Cited
2005
Highly Cited
2005
Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase catalytic… Expand
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Highly Cited
2001
Highly Cited
2001
  • I. Ward, J. Chen
  • The Journal of Biological Chemistry
  • 2001
  • Corpus ID: 23549540
H2AX, a member of the histone H2A family, is rapidly phosphorylated in response to ionizing radiation. This phosphorylation, at… Expand
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Highly Cited
2001
Highly Cited
2001
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair… Expand
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Highly Cited
2001
Highly Cited
2001
In response to DNA damage and blocks to replication, eukaryotes activate the checkpoint pathways that prevent genomic instability… Expand
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Highly Cited
2000
Highly Cited
2000
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By… Expand
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Highly Cited
2000
Highly Cited
2000
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been… Expand
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