ATR protein, human

Known as: FRAP-Related Protein-1, ATR serine-threonine kinase protein, human, Ataxia Telangiectasia and Rad3 Related Protein 
Serine/threonine-protein kinase ATR (2644 aa, ~301 kDa) is encoded by the human ATR gene. This protein plays a role in protein phosphorylation, DNA… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases are crucial regulatory proteins in… (More)
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Highly Cited
2005
Highly Cited
2005
During the evolution of cancer, the incipient tumour experiences ‘oncogenic stress’, which evokes a counter-response to eliminate… (More)
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Highly Cited
2003
Highly Cited
2003
The function of the ATR (ataxia-telangiectasia mutated- and Rad3-related)-ATRIP (ATR-interacting protein) protein kinase complex… (More)
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Highly Cited
2003
Highly Cited
2003
A Cre/lox-conditional mouse line was generated to evaluate the role of ATR in checkpoint responses to ionizing radiation (IR) and… (More)
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Highly Cited
2001
Highly Cited
2001
Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint activation. In… (More)
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Highly Cited
2000
Highly Cited
2000
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By… (More)
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Highly Cited
2000
Highly Cited
2000
The BRCA1 gene encodes a tumor suppressor that is mutated in 50% of familial breast cancers. The BRCA1 protein has been… (More)
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Highly Cited
1999
Highly Cited
1999
Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of… (More)
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Highly Cited
1999
Highly Cited
1999
Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress… (More)
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Highly Cited
1999
Highly Cited
1999
ATR is a large, >300 kDa protein containing a carboxy-terminus kinase domain related to PI-3 kinase, and is homologous to the ATM… (More)
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