APEX1 protein, human

Known as: APEX nuclease (multifunctional DNA repair enzyme) 1, human, Deoxyribonuclease (Apurinic or Apyrimidinic), APEX 
DNA-(apurinic or apyrimidinic site) lyase (318 aa, ~36 kDa) is encoded by the human APEX1 gene. This protein plays a role in both DNA repair and the… (More)

Topic mentions per year

Topic mentions per year

1935-2018
05010015019352017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The frequency, characteristics and reversibility of bortezomib-associated peripheral neuropathy were evaluated in the phase III… (More)
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Highly Cited
2007
Highly Cited
2007
We report a method for large-scale absolute protein expression measurements (APEX) and apply it to estimate the relative… (More)
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Highly Cited
2007
Highly Cited
2007
Initial analysis of the Assessment of Proteasome Inhibition for Extending Remissions (APEX) trial of relapsed multiple myeloma… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVES We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of… (More)
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Highly Cited
2002
Highly Cited
2002
To identify target genes of the oncogenic transcription factor c-MYC, serial analysis of gene expression (SAGE) was performed… (More)
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Highly Cited
2001
Highly Cited
2001
The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic sites generated either spontaneously, from… (More)
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Highly Cited
2001
Highly Cited
2001
Although several variants of DNA repair genes have been identified, their functional significance has not been determined. Using… (More)
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Highly Cited
2000
Highly Cited
2000
Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created in cells both spontaneously and by damage-specific DNA… (More)
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Highly Cited
1998
Highly Cited
1998
Apurinic/apyrimidinic (AP) endonuclease (APE; EC 4.2.99.18) plays a central role in repair of DNA damage due to reactive oxygen… (More)
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Highly Cited
1992
Highly Cited
1992
The Saccharomyces cerevisiae APE1 gene product, aminopeptidase I (API), is a soluble hydrolase that has been shown to be… (More)
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