• Publications
  • Influence
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
The dual specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal regulated kinase (ERK) 1 and 2.Expand
  • 196
  • 20
  • PDF
Low molecular weight inhibitors of Myc–Max interaction and function
c-Myc is helix–loop–helix–leucine zipper (HLH–ZIP) oncoprotein that is frequently deregulated in human cancers. In order to bind DNA, regulate target gene expression, and function in a biologicalExpand
  • 341
  • 19
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
Recent studies indicate that oxysterols, which are ligands for the nuclear hormone liver X receptors (LXR), decrease amyloid beta (Abeta) secretion in vitro. The effect was attributed primarily toExpand
  • 130
  • 12
The Substrate Recognition Domains of the N-end Rule Pathway*
The N-end rule pathway is a ubiquitin-dependent system where E3 ligases called N-recognins, including UBR1 and UBR2, recognize type-1 (basic) and type-2 (bulky hydrophobic) N-terminal residues asExpand
  • 94
  • 12
Overexpression of metallothionein confers resistance to anticancer drugs.
Resistance to antineoplastic agents is the major obstacle to curative therapy of cancer. Tumor cell lines with acquired resistance to the antineoplastic agent cis-diamminedichloroplatinum(II)Expand
  • 594
  • 11
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gainExpand
  • 286
  • 9
  • PDF
Chemical genetics of Plasmodium falciparum
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for mostExpand
  • 459
  • 8
  • PDF
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.
In inflammatory states, nitric oxide (.NO) may be synthesized from precursor L-arginine via inducible .NO synthase (iNOS) in large amounts for prolonged periods of time. When .NO acts as an effectorExpand
  • 244
  • 8
  • PDF
Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone*
Protein kinase D (PKD) is a novel family of serine/threonine kinases targeted by the second messenger diacylglycerol. It has been implicated in many important cellular processes and pathologicalExpand
  • 115
  • 8
  • PDF
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells.
Phosphatases of regenerating liver (PRL) constitute a subfamily of the protein tyrosine phosphatases that are implicated in oncogenic and metastatic phenotypes. In this study, we evaluated the roleExpand
  • 78
  • 8
  • PDF