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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
We have compared the substrate specificities of the BLM and WRN proteins using a variety of partial duplex DNA molecules, which are based upon a common core nucleotide sequence. Expand
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Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity*
  • R. Brosh, J. Li, +5 authors V. Bohr
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 4 August 2000
Bloom's syndrome is a rare autosomal recessive disorder characterized by genomic instability and predisposition to cancer. BLM, the gene defective in Bloom's syndrome, encodes a 159-kDa proteinExpand
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Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest
Individuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibitExpand
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FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability
ABSTRACT FANCJ mutations are associated with breast cancer and genetically linked to the bone marrow disease Fanconi anemia (FA). The genomic instability of FA-J mutant cells suggests that FANCJExpand
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Functional and Physical Interaction between WRN Helicase and Human Replication Protein A*
The human premature aging disorder Werner syndrome (WS) is associated with a large number of symptoms displayed in normal aging. The WRN gene product, a DNA helicase, has been previously shown toExpand
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DNA helicases involved in DNA repair and their roles in cancer
  • R. Brosh
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 August 2013
Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects.Expand
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Physical and Functional Mapping of the Replication Protein A Interaction Domain of the Werner and Bloom Syndrome Helicases*
The single-stranded DNA-binding protein replication protein A (RPA) interacts with several human RecQ DNA helicases that have important roles in maintaining genomic stability; however, the mechanismExpand
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The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells
FANCJ also called BACH1/BRIP1 was first linked to hereditary breast cancer through its direct interaction with BRCA1. FANCJ was also recently identified as a Fanconi anemia (FA) gene product,Expand
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Ku complex interacts with and stimulates the Werner protein.
Werner syndrome (WS) is the hallmark premature aging disorder in which affected humans appear older than their chronological age. The protein WRNp, defective in WS, has helicase function,Expand
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Detection of G-quadruplex DNA in mammalian cells
It has been proposed that guanine-rich DNA forms four-stranded structures in vivo called G-quadruplexes or G4 DNA. G4 DNA has been implicated in several biological processes, but tools to study G4Expand
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