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Hedgehog signaling in animal development: paradigms and principles.
In their screen for mutations that disrupt the Drosophila larval body plan, these authors identified several that cause the duplication of denticles and an accompanying loss of naked cuticle, characteristic of the posterior half of each segment.
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.
A transgenic mouse line is generated in which Cre-ER is ubiquitously expressed to permit temporally regulated Cre-mediated recombination in diverse tissues of the mouse at embryonic and adult stages and this inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration.
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
Analysis of an Ihh null mutant and results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes.
Female development in mammals is regulated by Wnt-4 signalling
In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development but the establishment of sexual dimorphism is under the control of both local and systemic signals.
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
The results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development, and analysis of neural tube explants shows that (beta- catenin is efficiently deleted in migrating neural crest cell precursors), suggests that removal of Beta-Catenin affects Neural crest cell survival and/or differentiation.
Fate of the mammalian cardiac neural crest.
A two-component genetic system based on Cre/lox recombination is employed to label indelibly the entire mouse neural crest population at the time of its formation, and to detect it at any time thereafter.
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
It is demonstrated that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite.