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Hedgehog signaling in animal development: paradigms and principles.
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonicExpand
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Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. When genetic modifications have been generated in the germ line, however, theExpand
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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
We have identified three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh). Like hh, they encode putative secreted proteins and are thus implicated inExpand
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Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.
In recent years, the Cre integrase from bacteriophage P1 has become an essential tool for conditional gene activation and/or inactivation in mouse. In an earlier report, we described a fusion proteinExpand
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Female development in mammals is regulated by Wnt-4 signalling
In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development. Müllerian inhibiting substance and testosteroneExpand
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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) signaling fromExpand
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Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis.Expand
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Fate of the mammalian cardiac neural crest.
A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalianExpand
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Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
beta-Catenin is a central component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway. We have investigated the role of beta-catenin during brain morphogenesis, byExpand
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Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
Embryonic patterning in vertebrates is dependent upon the balance of inductive signals and their specific antagonists. We show that Noggin, which encodes a bone morphogenetic protein (BMP) antagonistExpand
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