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Patients with non-small-cell lung cancer harbouring mutations in the epidermal growth factor receptor (EGFR) gene… Expand PURPOSE
The risk of local and regional relapse associated with each breast cancer molecular subtype was determined in a large… Expand The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find… Expand BACKGROUND
Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that constitutes one of four members of the erbB… Expand CONTEXT
More persons in the United States die from non-small cell lung cancer (NSCLC) than from breast, colorectal, and prostate… Expand PURPOSE
Expression of ErbB-1 and ErbB-2 (epidermal growth factor receptor and HER2/neu) in breast cancer may cause tamoxifen… Expand Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of… Expand TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… Expand Epidermal growth factor (EGF), through interaction with specific cell surface receptors, generates a pleiotropic response that… Expand