Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, G. Kroemer
- BiologyCell Death and Differentiation
- 23 January 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
- D. J. Giard, S. Aaronson, W. Parks
- Chemistry, MedicineJournal of the National Cancer Institute
- 1 November 1973
A rapid in vitro assay for quantitating the invasive potential of tumor cells.
- A. Albini, Y. Iwamoto, R. McEwan
- Biology, MedicineCancer Research
- 15 June 1987
The results suggest that this in vitro test allows the rapid and quantitative assessment of invasiveness and a means to screen for drugs which alter the invasive phenotype of tumor cells.
Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis
- R. Hazan, G. Phillips, R. Qiao, L. Norton, S. Aaronson
- Biology, MedicineJournal of Cell Biology
- 21 February 2000
It is demonstrated that N-cadherin promotes motility, invasion, and metastasis even in the presence of the normally suppressive E-c adhesion molecules, and the increase in their adherence to endothelium may improve their ability to enter and exit the vasculature, two properties that may be responsible for metastasis of N- cadher in–expressing cells.
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
- A. Bafico, Guizhong Liu, A. Yaniv, A. Gazit, S. Aaronson
- BiologyNature Cell Biology
- 1 July 2001
Unlike Wnt antagonists, which exert their effects by molecular mimicry of Fz or Wnt sequestration through other mechanisms, Dkk-1 specifically inhibits canonical Wnt signalling by binding to the LRP6 component of the receptor complex.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
- L. Galluzzi, S. Aaronson, G. Kroemer
- BiologyCell Death and Differentiation
- 17 April 2009
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.
- T. Miki, D. Bottaro, S. Aaronson
- BiologyProceedings of the National Academy of Sciences…
- 1992
Two growth factor receptors with different ligand-binding specificities and expression patterns are encoded by alternative transcripts of the same gene, as revealed by cDNA cloning and structural analysis of the KGFR.
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
- M. Kraus, W. Issing, T. Miki, N. Popescu, S. Aaronson
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1989
Findings suggest that increased ERBB3 expression, as in the case of epidermal growth factor receptor and ERBB2, may play a role in some human malignancies.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- L. Galluzzi, J. M. Bravo-San Pedro, G. Kroemer
- BiologyCell Death and Differentiation
- 19 September 2014
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.
- L. Grumolato, Guizhong Liu, S. Aaronson
- BiologyGenes & Development
- 15 November 2010
It is demonstrated here that prototype canonical Wnt3a and noncanonical Wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-LRP5/6 and Ror1/2, respectively-through a common mechanism that involves their Wnt-dependent coupling to the Frizzled (Fzd) coreceptor and recruitment of shared components.
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