Cell Signaling by Receptor Tyrosine Kinases
- J. Schlessinger
- Biology, ChemistryCell
- 13 October 2000
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.
- D. Axelrod, D. Koppel, J. Schlessinger, E. Elson, W. Webb
- BiologyBiophysical Journal
- 1 September 1976
Cell Signaling by Receptor Tyrosine Kinases
- M. Lemmon, J. Schlessinger
- BiologyCell
- 13 October 2000
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
- M. Mohammadi, G. Mcmahon, J. Schlessinger
- Chemistry, BiologyScience
- 9 May 1997
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast growth…
Cellular signaling by fibroblast growth factor receptors.
- V. P. Eswarakumar, I. Lax, J. Schlessinger
- BiologyCytokine & growth factor reviews
- 1 April 2005
Signal transduction by receptors with tyrosine kinase activity
- A. Ullrich, J. Schlessinger
- Biology, MedicineCell
- 20 April 1990
Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions
- S. Lev, H. Moreno, J. Schlessinger
- Biology, Computer ScienceNature
- 31 August 1995
PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
- I. Dikic, G. Tokiwa, S. Lev, S. Courtneidge, J. Schlessinger
- Biology, ChemistryNature
- 10 October 1996
It is proposed that Pyk2 acts with Src to link Gi- and Gq-coupled receptors with Grb2 and Sos to activate the MAP kinase signalling pathway in PC12 cells.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- M. Krauthammer, Y. Kong, R. Halaban
- BiologyNature Genetics
- 9 July 2012
Crystal structures, biochemical and functional studies of RAC1P29S showed that the alteration releases the conformational restraint conferred by the conserved proline, causes an increased binding of the protein to downstream effectors, and promotes melanocyte proliferation and migration, raising the possibility that pharmacological inhibition of downstream effector of Rac1 signaling could be of therapeutic benefit.
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