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Cell Signaling by Receptor Tyrosine Kinases
Receptor dimerization is of most fundamental cellular processes including the further stabilized by additional receptor:receptor inter-cell cycle, cell migration, cell metabolism and survival, actions. Expand
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.
The theoretical basis and some practical guidelines for simple, rigorous analysis of FPR experiments are presented and some model experiments on aqueous solutions of rhodamine 6G are described. Expand
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast growthExpand
Cell Signaling by Receptor Tyrosine Kinases
Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases. Expand
Cellular signaling by fibroblast growth factor receptors.
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptorExpand
Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions
PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system. Expand
Signal transduction by receptors with tyrosine kinase activity
Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction et notamment jouent le role de signal de la transduction
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
It is proposed that Pyk2 acts with Src to link Gi- and Gq-coupled receptors with Grb2 and Sos to activate the MAP kinase signalling pathway in PC12 cells. Expand
A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway
It is found that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation. Expand
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals closeExpand