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Growth Factor Receptors

Known as: Growth Factor, Receptor, Growth Factors Receptors, Growth Factor Receptor 
A class of cell surface proteins that bind to extracellular polypeptide molecules triggering intracellular signaling pathways that activate various… 
National Institutes of Health

Related topics

Related topics

48 relations
Activin ReceptorCell Proliferation Regulatory ProcessEGFR protein, humanERBB2 Gene Product
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Narrower (7)

Epidermal Growth Factor ReceptorInsulin ReceptorVEGF Trap R1R2 proteinagrin receptor
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Broader (2)

Receptors, Cell Surfacereceptor

Papers overview

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Highly Cited
2010
Highly Cited
2010
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised…
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Review
2007
Review
2007
Epidermal growth factor receptor mutations in lung cancer
The development and clinical application of inhibitors that target the epidermal growth factor receptor (EGFR) provide important… 
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Review
2007
Review
2007
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.
PURPOSE To develop a guideline to improve the accuracy of human epidermal growth factor receptor 2 (HER2) testing in invasive… 
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Highly Cited
2006
Highly Cited
2006
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.
PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in… 
Highly Cited
2005
Highly Cited
2005
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
BACKGROUND Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are… 
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Highly Cited
2004
Highly Cited
2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… 
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Highly Cited
2003
Highly Cited
2003
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic…
One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising… 
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Highly Cited
1991
Highly Cited
1991
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145… 
Highly Cited
1984
Highly Cited
1984
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced… 
Highly Cited
1984
Highly Cited
1984
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones… 
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