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Growth Factor Receptors

Known as: Growth Factor, Receptor, Growth Factors Receptors, Growth Factor Receptor 
A class of cell surface proteins that bind to extracellular polypeptide molecules triggering intracellular signaling pathways that activate various… Expand
National Institutes of Health

Related topics

Related topics

48 relations
Activin ReceptorCell Proliferation Regulatory ProcessEGFR protein, humanERBB2 Gene Product
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Narrower (7)

Epidermal Growth Factor ReceptorInsulin ReceptorVEGF Trap R1R2 proteinagrin receptor
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Broader (2)

Receptors, Cell Surfacereceptor

Papers overview

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Highly Cited
2010
Highly Cited
2010
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial…
BACKGROUND Patients with non-small-cell lung cancer harbouring mutations in the epidermal growth factor receptor (EGFR) gene… Expand
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Review
2006
Review
2006
Epidermal growth factor receptor (EGFR) signaling in cancer.
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane… Expand
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Highly Cited
2006
Highly Cited
2006
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.
PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in… Expand
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Highly Cited
2005
Highly Cited
2005
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
BACKGROUND Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are… Expand
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Highly Cited
2005
Highly Cited
2005
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.
BACKGROUND Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand
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Highly Cited
2004
Highly Cited
2004
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.
PURPOSE To evaluate the antitumor activity and toxicity of single-agent cetuximab in patients with chemotherapy-refractory… Expand
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Highly Cited
2003
Highly Cited
2003
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic…
One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising… Expand
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Highly Cited
2003
Highly Cited
2003
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.
CONTEXT More persons in the United States die from non-small cell lung cancer (NSCLC) than from breast, colorectal, and prostate… Expand
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Highly Cited
1991
Highly Cited
1991
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145… Expand
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