Receptor Protein-Tyrosine Kinases

Known as: Receptor Protein Tyrosine Kinases, Tyrosine Kinase Growth Factor Receptor, Protein-Tyrosine Kinase Receptors 
A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the receptor as a… (More)

Topic mentions per year

Topic mentions per year

1980-2018
050019802018

Papers overview

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Review
2016
Review
2016
Patients with advanced melanoma have traditionally had very poor prognosis. However, since 2011 better understanding of the… (More)
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Highly Cited
2011
Highly Cited
2011
Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream… (More)
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Highly Cited
2007
Highly Cited
2007
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
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Highly Cited
2003
Highly Cited
2003
One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising… (More)
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Highly Cited
2003
Highly Cited
2003
CONTEXT More persons in the United States die from non-small cell lung cancer (NSCLC) than from breast, colorectal, and prostate… (More)
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Highly Cited
2000
Highly Cited
2000
STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and platelet-derived growth-factor receptor… (More)
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Highly Cited
1999
Highly Cited
1999
Prostate cancer progresses from a hormone-sensitive, androgen-dependent stage to a hormone-refractory, androgen-independent tumor… (More)
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Highly Cited
1996
Highly Cited
1996
Angiogenesis, the sprouting of new blood vessels from pre-existing ones, and the permeability of blood vessels are regulated by… (More)
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Highly Cited
1996
Highly Cited
1996
Transduction of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… (More)
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