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Receptor Protein-Tyrosine Kinases

Known as: Receptor Protein Tyrosine Kinases, Tyrosine Kinase Growth Factor Receptor, Protein-Tyrosine Kinase Receptors 
A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the receptor as a… 
National Institutes of Health

Related topics

Related topics

50 relations
Cell Differentiation processCell ProliferationEnzyme GeneImatinib mesylate

Narrower (21)

DRL protein, DrosophilaEPHA3 protein, humanEphA3 ReceptorEphrin Receptor EphB1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify… 
Review
2008
Review
2008
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
Although patients with advanced refractory solid tumors have poor prognosis, the clinical development of targeted protein kinase… 
Highly Cited
2004
Highly Cited
2004
BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis
The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. The novel bi-aryl urea BAY… 
Review
2004
Review
2004
The discovery of receptor tyrosine kinases: targets for cancer therapy
Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine… 
Review
2003
Review
2003
The biology of VEGF and its receptors
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth… 
Review
2001
Review
2001
Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases
  • S. Shiu, A. Bleecker
  • Proceedings of the National Academy of Sciences…
  • 2001
  • Corpus ID: 25882718
Plant receptor-like kinases (RLKs) are proteins with a predicted signal sequence, single transmembrane region, and cytoplasmic… 
Highly Cited
2000
Highly Cited
2000
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.
STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and platelet-derived growth-factor receptor… 
Highly Cited
1999
Highly Cited
1999
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… 
Review
1995
Review
1995
Protein Kinase C: Structure, Function, and Regulation (*)
  • A. Newton
  • The Journal of Biological Chemistry
  • 1995
  • Corpus ID: 28248489
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme… 
Review
1995
Review
1995
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
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