• Publications
  • Influence
Molecular genetic basis of the histo-blood group ABO system
TLDR
A critical single-base deletion was found in the 0 gene, which results in an entirely different, inactive protein incapable of modifying the H antigen, and this work presents a molecular basis for the ABO genotypes. Expand
Glycosylation defining cancer malignancy: New wine in an old bottle
  • S. Hakomori
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 30 July 2002
TLDR
The concept of glycosylation-dependent promotion or inhibition of tumor progression has developed in conjunction with clinicopathological studies and appears to be considered “in the shade” of more popular topics such as oncogenes and antioncogene, apoptosis, angiogenesis, growth factor receptors, integrin and caderin function, etc., despite the fact that aberrant glycosYLation profoundly affects all of these processes. Expand
Stage‐specific embryonic antigens (SSEA‐3 and ‐4) are epitopes of a unique globo‐series ganglioside isolated from human teratocarcinoma cells.
Two monoclonal antibodies (MC631 and MC813‐70) raised against 4‐ to 8‐cell stage mouse embryos and a human teratocarcinoma cell line, respectively, detect the stage‐specific embryonic antigens, theExpand
A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE.
  • S. Hakomori
  • Chemistry, Medicine
  • Journal of biochemistry
  • 25 February 1964
TLDR
It was undertaken to demonstrate the presence of various kinds of acyl residue in this solvent by ` hydroxylaminolysis' of the urinary glyco protein. Expand
Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
TLDR
Although Ran-1 is expressed on glial and neuronal tumours, it was not found on normal astrocytes, oligodendrocyte or neurons and the 'large external transformation sensitive' (LETS) protein could be detected on fibroblasts and leptomeningeal cells but not on neurons or glial cells. Expand
Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.
  • S. Hakomori
  • Biology, Medicine
  • Cancer research
  • 1 December 1996
Aberrant glycosylation expressed in glycosphingolipids and glycoproteins in tumor cells has been implicated as an essential mechanism in defining stage, direction, and fate of tumor progression. ThisExpand
Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.
  • S. Hakomori
  • Chemistry, Medicine
  • Annual review of biochemistry
  • 1981
TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary. Expand
Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens.
  • S. Hakomori
  • Biology, Medicine
  • Advances in cancer research
  • 1989
TLDR
Aberrant glycosylation as such may be the basis of inappropriate cell/cell and cell/matrix interactions that may be reflected in the abnormal cell social behavior of tumor cells, such as uncontrolled cell growth, invasiveness, and metastatic potential. Expand
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
TLDR
Cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils. Expand
Characterization of sialosylated Lewisx as a new tumor-associated antigen.
TLDR
Results indicate that the CSLEX1 epitope has the following structure: These results indicate that this structure had not previously been known to be tumor associated. Expand
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