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Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.
TLDR
It is concluded that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research. Expand
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.
TLDR
The merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance, including the quantitative insulin sensitivity check index, are highlighted. Expand
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms
Endothelial dysfunction contributes to cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. InsulinExpand
Cardiovascular actions of insulin.
TLDR
Molecular mechanisms underlying cardiovascular actions of insulin, the reciprocal relationships between insulin resistance and endothelial dysfunction, and implications for developing beneficial therapeutic strategies that simultaneously target metabolic and cardiovascular diseases are discussed. Expand
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
TLDR
It is suggested that IRS- 1 is a novel direct substrate for IKK and that phosphorylation of IRS-1 at Ser(312) (and other sites) by IKK may contribute to the insulin resistance mediated by activation of inflammatory pathways. Expand
A mathematical model of metabolic insulin signaling pathways.
TLDR
A mathematical model that explicitly represents many of the known signaling components mediating translocation of the insulin-responsive glucose transporter GLUT4 is developed and concludes that mathematical modeling of signal transduction pathways is a useful approach for gaining insight into the complexities of metabolic insulin signaling. Expand
Brain Insulin Receptors and Spatial Memory
TLDR
The findings suggest that IR may participate in memory processing through activation of its receptor Tyr kinase activity, and they suggest possible engagement of Shc/Grb-2/Ras/mitogen-activated protein kinase cascades. Expand
Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.
  • G. Zeng, M. Quon
  • Medicine, Biology
  • The Journal of clinical investigation
  • 15 August 1996
TLDR
The data suggest that NO is a novel effector of insulin signaling pathways that are also involved with glucose metabolism, and that PI 3-kinase activity is required for insulin-stimulated glucose transport. Expand
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin resistance may involve the phosphorylation of serine residues in insulinExpand
Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179 *
Vasodilator actions of insulin are mediated by activation of endothelial nitric-oxide synthase (eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play important roles inExpand
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