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γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase
TLDR
A subsequent cleavage by γ-secretase that releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus is reported. Expand
ErbB-4: mechanism of action and biology.
  • G. Carpenter
  • Biology, Medicine
  • Experimental cell research
  • 10 March 2003
TLDR
There are several novel aspects to its structure, mechanism of action, and biology including the spectrum of ligands that activate ErbB-4, the presence of functionally distinct isoforms, a proteolytic processing pathway to the nucleus, and the capacity to induce a spectrum of cellular responses such as mitogenesis, differentiation, growth inhibition, and survival. Expand
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
TLDR
It is suggested that Her2(YVMA) activates cellular substrates more potently than HER2(WT); and cancer cells expressing this mutation remain sensitive to HER2-targeted therapies but insensitive to EGFR TKIs. Expand
ErbB receptors: new insights on mechanisms and biology.
TLDR
Several aspects of ErbB receptor physiology for which new and significant information is available are reviewed, including ligand-dependent receptor dimerization and kinase activation, which is a prerequisite for all subsequent growth factor-dependent cell responses. Expand
Receptors for epidermal growth factor and other polypeptide mitogens.
  • G. Carpenter
  • Biology, Medicine
  • Annual review of biochemistry
  • 1987
EPIDERMAL GROWTH FACTOR *
During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extractExpand
The juxtamembrane region of the EGF receptor functions as an activation domain.
TLDR
How an uncharacterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR by augmenting its capacity to act as an acceptor in the asymmetric dimer is described. Expand
Phospholipase C-gamma as a signal-transducing element.
TLDR
The biochemistry of PLC-gamma is at a more advanced state than a clear understanding of exactly how this signaling element functions in the generation of a mitogenic response is clear. Expand
Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways
  • G. Carpenter
  • Biology, Medicine
  • The Journal of cell biology
  • 23 August 1999
TLDR
The data not only show EGF-independent tyrosine phosphorylation of the EGF receptor, but also provide experimental evidence that the E GF receptor participates in the signaling events and cellular responses initiated by these various stimuli. Expand
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression.
TLDR
It is reported that, after the addition of EGF, the cell surface EGF receptor is trafficked to the endoplasmic reticulum (ER) where it associates with Sec61beta, a component of the Sec61 translocon, and is retrotranslocated from the ER to the cytoplasm. Expand
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