Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages.
Analysis of the blood and bone marrow of the lys-EGFP mice revealed that most myelomonocytic cells, especially mature neutrophil granulocytes, were fluorescence-positive, while cells from other lineages were not, and removing the neo gene through breeding of the mice with the Cre-deleter strain led to an increased fluorescence intensity.
A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors
- J. Wyckoff, Weigang Wang, J. Condeelis
- Biology, MedicineCancer Research
- 1 October 2004
This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophage may contribute to metastasis.
Stepwise Reprogramming of B Cells into Macrophages
- Huafeng Xie, M. Ye, R. Feng, T. Graf
- BiologyCell
- 28 May 2004
Human Monocytes Engage an Alternative Inflammasome Pathway.
- Moritz M Gaidt, Thomas Ebert, V. Hornung
- BiologyImmunity
- 19 April 2016
Faculty Opinions recommendation of Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
- T. Graf
- Biology
- 26 November 2007
Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation
- H. Beug, A. V. Kirchbach, G. Döderlein, Jean-Francois Conscience, T. Graf
- Biology, MedicineCell
- 1 October 1979
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation
- A. Lim, Yan Li, J. P. Santo
- BiologyCell
- 9 March 2017
CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.
Transplantation experiments indicated that CD41-KO-associated defects are long-term transplantable, HSC-derived and, in part, mediated through the loss of platelet mass leading to decreases in HSC exposure to important platelet released cytokines, such as transforming growth factor β1.
The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
- S. Ness, Ã…sa Marknell, T. Graf
- BiologyCell
- 22 December 1989
Forcing cells to change lineages
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells…
...
...