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The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development
TLDR
It is demonstrated that So and Eya regulate common steps in eye development including cell proliferation, patterning, and neuronal development; synergize in inducing ectopic eyes; and interact in yeast and in vitro through evolutionarily conserved domains. Expand
Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
TLDR
CDNA and genomic analyses reveal the existence of multiple forms of Dscam with a conserved architecture containing variable Ig and transmembrane domains, which may contribute to the specificity of neuronal connectivity. Expand
The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
TLDR
Molecular and developmental analyses reveals that the sine oculis (so) locus encodes a homeodomain-containing protein that is expressed and required in the unpatterned epithelium prior to morphogenesis, and argues that so plays an essential role in controlling the initial events of pattern formation in the eye disc. Expand
Induction of Drosophila eye development by decapentaplegic.
TLDR
Ectopic Dpp expression is shown to be sufficient to induce a duplicated eye disc with normal shape, MF progression, neuronal cluster formation and direction of axon outgrowth, and Dpp positively controls its own expression and suppresses wingless transcription. Expand
Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1
TLDR
It is proposed that JAMM isopeptidases play important roles in a variety of physiological pathways, including the Rpn11 subunit of the 26S proteasome and both viability and proper photoreceptor cell (R cell) development in Drosophila melanogaster required an intact Csn5 JAMm domain. Expand
Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila
TLDR
It is demonstrated that Drosophila p21-activated kinase (Pak) is required in a Dock pathway regulating R cell axon guidance and targeting, and Retinal expression of Pak rescues the R cell connectivity phenotype in dock mutants, establishing Pak as a critical regulator of axon advice and a downstream effector of Dock in vivo. Expand
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
TLDR
A gain-of-function mutation in rolled is identified (rlSevenmaker [rlSem], which encodes a homolog of mitogen-activated protein (MAP) kinase, which activation of MAP kinase by the rlSem mutation is both necessary and sufficient to activate multiple signaling pathways controlled by receptor tyrosine kinases. Expand
Homeobox genes and connective tissue patterning.
TLDR
Two murine homeobox-containing genes, Six 1 and Six 2, which are expressed in a complementary fashion during the development of limb tendons are identified and may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes. Expand
Monoclonal antibodies against the Drosophila nervous system.
TLDR
Monoclonal antibodies that identify specific molecules within the nervous system should prove useful in the study of the molecular genetics of neural development. Expand
Design Principles of Insect and Vertebrate Visual Systems
TLDR
It is argued that vertebrate and fly visual circuits utilize common design principles and that taking advantage of this phylogenetic conservation will speed progress in elucidating both functional strategies and developmental mechanisms, as has already occurred in other areas of neurobiology. Expand
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