epidermal growth factor receptor VIII

Known as: EGFRvIII 
 
National Institutes of Health

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EGFR NP_005219.2:p.K29_N298insG

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Epidermal Growth Factor Receptor

Papers overview

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2015
2015
Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells
Glioblastoma Multiforme (GBM) is the most common and aggressive human brain tumor, associated with very poor survival despite… (More)
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2015
2015
Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma.
BACKGROUND The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor and is overexpressed in up to… (More)
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2013
2013
EGFR and EGFRvIII in glioblastoma: partners in crime.
EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis, but the underlying mechanisms have remained elusive… (More)
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Highly Cited
2013
Highly Cited
2013
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but… (More)
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2012
2012
Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation
Formation of asymmetric kinase dimers is required for wt-EGFR activation upon ligand stimulation. The role of receptor… (More)
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2008
2008
LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII
Epidermal growth factor receptor (EGFR) mutation is frequently observed in human cancer and contributes to the growth, survival… (More)
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Highly Cited
2007
Highly Cited
2007
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
EGFRvIII is a mutant variant of the epidermal growth factor receptor (EGFR) found exclusively in various cancer types. EGFRvIII… (More)
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Highly Cited
2006
Highly Cited
2006
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.
PURPOSE Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where… (More)
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2006
2006
Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4.
PURPOSE The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron… (More)
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Highly Cited
1997
Highly Cited
1997
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
The type-III deletion variant of the epidermal growth factor receptor (EGFRvIII) is frequently found in glioblastomas and other… (More)
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