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epidermal growth factor receptor VIII

Known as: EGFRvIII 
 
National Institutes of Health

Related topics

Related topics

2 relations
EGFR NP_005219.2:p.K29_N298insG

Broader (1)

Epidermal Growth Factor Receptor

Papers overview

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Highly Cited
2017
Highly Cited
2017
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII… Expand
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Highly Cited
2013
Highly Cited
2013
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but… Expand
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Highly Cited
2013
Highly Cited
2013
EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms
Amplification and rearrangements of the epidermal growth factor receptor (EGFR) gene are frequently found in glioblastoma… Expand
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Highly Cited
2011
Highly Cited
2011
Expression of EGFRvIII in glioblastoma: prognostic significance revisited.
The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased proliferation of glioma cells. However… Expand
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Highly Cited
2009
Highly Cited
2009
EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
Receptor tyrosine kinase (RTK) systems, such as hepatocyte growth factor (HGF) and its receptor c-Met, and epidermal growth… Expand
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Highly Cited
2007
Highly Cited
2007
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
EGFRvIII is a mutant variant of the epidermal growth factor receptor (EGFR) found exclusively in various cancer types. EGFRvIII… Expand
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Highly Cited
2006
Highly Cited
2006
Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
Purpose: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where… Expand
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Highly Cited
2006
Highly Cited
2006
Molecular Targeting and Treatment of EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibody L8A4
Purpose: The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron… Expand
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Highly Cited
2005
Highly Cited
2005
Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer.
In colorectal cancer, epidermal growth factor receptor (EGFR) expression is reported in 8-100% of the cases examined and there… Expand
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Highly Cited
1997
Highly Cited
1997
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
The type-III deletion variant of the epidermal growth factor receptor (EGFRvIII) is frequently found in glioblastomas and other… Expand
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