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epidermal growth factor receptor VIII

Known as: EGFRvIII 
National Institutes of Health

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2 relations
EGFR NP_005219.2:p.K29_N298insG

Broader (1)

Epidermal Growth Factor Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
An EGFR wild type–EGFRvIII–HB-EGF feed-forward loop regulates the activation of EGFRvIII
EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in-frame deletion in the extracellular domain of EGFR… 
Highly Cited
2013
Highly Cited
2013
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
Highly Cited
2011
Highly Cited
2011
Expression of EGFRvIII in glioblastoma: prognostic significance revisited.
The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased proliferation of glioma cells. However… 
Highly Cited
2009
Highly Cited
2009
Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis
Abstract Epidermal growth factor receptor variant III (EGFRvIII) is a glycoprotein uniquely expressed in glioblastoma, but not in… 
Highly Cited
2009
Highly Cited
2009
EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
Receptor tyrosine kinase (RTK) systems, such as hepatocyte growth factor (HGF) and its receptor c-Met, and epidermal growth… 
2009
2009
Genetic modification of mesenchymal stem cells to express a single‐chain antibody against EGFRvIII on the cell surface
Human adult mesenchymal stem cells (hMSCs) are under active investigation as cellular carriers for gene therapy. hMSCs possess… 
Highly Cited
2007
Highly Cited
2007
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
EGFRvIII is a mutant variant of the epidermal growth factor receptor (EGFR) found exclusively in various cancer types. EGFRvIII… 
Highly Cited
2006
Highly Cited
2006
Molecular Targeting and Treatment of EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibody L8A4
Purpose: The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron… 
Highly Cited
2005
Highly Cited
2005
Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer.
In colorectal cancer, epidermal growth factor receptor (EGFR) expression is reported in 8-100% of the cases examined and there… 
Highly Cited
1997
Highly Cited
1997
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
The type-III deletion variant of the epidermal growth factor receptor (EGFRvIII) is frequently found in glioblastomas and other… 
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