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epidermal growth factor receptor VIII

Known as: EGFRvIII 
National Institutes of Health

Related topics

Related topics

2 relations
EGFR NP_005219.2:p.K29_N298insG

Broader (1)

Epidermal Growth Factor Receptor

Papers overview

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Highly Cited
2017
Highly Cited
2017
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII… Expand
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Highly Cited
2014
Highly Cited
2014
JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.
BACKGROUND As a commonly mutated form of the epidermal growth factor receptor, EGFRvIII strongly promotes glioblastoma (GBM… Expand
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Highly Cited
2013
Highly Cited
2013
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but… Expand
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Highly Cited
2011
Highly Cited
2011
Expression of EGFRvIII in glioblastoma: prognostic significance revisited.
The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased proliferation of glioma cells. However… Expand
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Review
2009
Review
2009
The EGFRvIII variant in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst prognosis. Epidermal growth factor receptor (EGFR… Expand
Highly Cited
2009
Highly Cited
2009
Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis
Abstract Epidermal growth factor receptor variant III (EGFRvIII) is a glycoprotein uniquely expressed in glioblastoma, but not in… Expand
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Highly Cited
2007
Highly Cited
2007
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
EGFRvIII is a mutant variant of the epidermal growth factor receptor (EGFR) found exclusively in various cancer types. EGFRvIII… Expand
Highly Cited
2006
Highly Cited
2006
Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
Purpose: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where… Expand
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Highly Cited
2005
Highly Cited
2005
Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer.
In colorectal cancer, epidermal growth factor receptor (EGFR) expression is reported in 8-100% of the cases examined and there… Expand
Highly Cited
1997
Highly Cited
1997
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
The type-III deletion variant of the epidermal growth factor receptor (EGFRvIII) is frequently found in glioblastomas and other… Expand
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