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Mutations of the BRAF gene in human cancer
BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
The Somatic Genomic Landscape of Glioblastoma
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival.
The Immune Landscape of Cancer
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.
Data indicate that stem cell-like tumor cells can be a crucial source of key angiogenic Factors in cancers and that targeting proangiogenic factors from stem cell -like tumor populations may be critical for patient therapy.
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
- P. Killela, Z. Reitman, Hai Yan
- Biology, MedicineProceedings of the National Academy of Sciences
- 25 March 2013
TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Altered Telomeres in Tumors with ATRX and DAXX Mutations
The data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes, which are common in human pancreatic neuroendocrine tumors.
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
The genetic signatures distinguished clinically distinct groups of oligoastrocytoma patients, which usually present a diagnostic challenge, and were associated with differences in clinical outcome even among individual tumor types.