Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling
This is the first report to outline the site and molecular mechanism of action of SHP2 in EGFR signaling, which may also serve as a model to describe its role in other receptor tyrosine kinase signaling pathways.
Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail
- C. Moscovici, M. Moscovici, Humberto Jimenez, M. Lai, M. Hayman, P. Vogt
- BiologyCell
- 1 May 1977
Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.
- K. Keegan, D. Johnson, L. Williams, M. Hayman
- BiologyProceedings of the National Academy of Sciences…
- 15 February 1991
The existence of an additional member of the FGFR family that is highly homologous to the previously described FGFR-3 is established by showing that human acidic and basic fibroblast growth factors activate this receptor as measured by 45Ca2+ efflux assays.
The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42
- R. Dahl, Bushra Wani, M. Hayman
- BiologyOncogene
- 26 March 1998
The human gene skip (Ski Interacting Protein) was identified as encoding a protein which interacts with both the cellular and viral forms of Ski in the two-hybrid system.
Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.
- R. Dahl, M. Kieslinger, H. Beug, M. Hayman
- BiologyProceedings of the National Academy of Sciences…
- 15 September 1998
It is demonstrated that Ski associates with the RAR complex and can repress transcription from a retinoic acid response element and the results strongly suggest that the ability of Ski to alter cell differentiation is caused in part by the modulation of RAR signaling pathways.
Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member.
- Jennifer M O'Toole, K. Rabenau, D. Pereira
- Biology, MedicineCancer Research
- 15 September 2006
This is the first demonstration that a RON antagonist and specifically an inhibitory antibody of RON negatively affects tumorigenesis, and highlights the potential therapeutic usefulness of Ron activity inhibition in human cancers.
Development of an Efficient “Substrate-trapping” Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as…
The double mutant (DM) protein identified the epidermal growth factor receptor (EGFR), the Grb2 binder 1, and three other, as yet unidentified, phosphotyrosyl proteins as candidate physiological substrates of SHP2 and constructed a potent trapping mutant ofSHP2.
Ski-interacting Protein Interacts with Smad Proteins to Augment Transforming Growth Factor-β-dependent Transcription*
- G. Leong, N. Subramaniam, A. Kouzmenko
- Biology, ChemistryJournal of Biological Chemistry
- 25 May 2001
The results suggest a potential mechanism for transcriptional control of TGF-β signaling that involves the opposing and competitive actions of SKIP and Smad MH2-interacting factors, such as Ski and/or Sno.
Characterization of a member of the immunoglobulin gene superfamily that possibly represents an additional class of growth factor receptor.
Observations raise the possibility that the klg gene product represents a newly discovered class of receptor that plays a role in signal attenuation rather than signal propagation.
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