• Publications
  • Influence
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.
A correlative study was performed to address the impact of epidermal growth factor receptor (EGFR) overexpression on survival and pattern of failure in patients with advanced head and neck squamousExpand
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  • Open Access
Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase*
Ionizing radiation, but not stimulation with epidermal growth factor (EGF), triggers EGF receptor (EGFR) import into the nucleus in a probably karyopherin α-linked manner. An increase in nuclear EGFRExpand
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Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor.
The antitumor effects of the selective cyclooxygenase (COX)-2 inhibitor SC-236 alone and in combination with radiation were investigated using the human glioma cell line U251 grown in monolayerExpand
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  • Open Access
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.
  • L. Milas, K. Mason, +5 authors Z. Fan
  • Medicine
  • Clinical cancer research : an official journal of…
  • 1 February 2000
Overexpression of epidermal growth factor receptor (EGFR) has been correlated with tumor resistance to cytotoxic agents, including radiation (T. Akimoto et al., Clin. Cancer Res., 5: 2884-2890,Expand
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  • Open Access
Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance?
  • H. Choy, L. Milas
  • Medicine
  • Journal of the National Cancer Institute
  • 1 October 2003
Results of preclinical studies suggesting that the efficacy of molecular therapies is enhanced when they are combined with radiation have generated a surge of clinical trials combining theseExpand
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  • Open Access
Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel.
BACKGROUND Microtubules are cellular organelles with functions that include control of cell division by mitosis, cell morphology, and transport of material within the cell. The anticancer drugExpand
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  • Open Access
Macrophage content of murine sarcomas and carcinomas: associations with tumor growth parameters and tumor radiocurability.
Experiments were designed to investigate whether the tumor-associated macrophage (TAM) content of murine solid tumors correlates with the clonogenic ability of tumor cells to establish s.c. tumors,Expand
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Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive
PURPOSE In search of reliable biologic markers to predict the risk of normal tissue damage by radio(chemo)therapy before treatment, we investigated the association between single nucleotideExpand
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Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy.
PURPOSE To present an overview of the significance of erbB tyrosine kinase family members as prognostic-predictive factors and as targets of therapeutic intervention in patients with head-and-neckExpand
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Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor.
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, where it mediates production of prostaglandins (PGs), which in turn may stimulateExpand
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  • Open Access