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Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.
This correlative study in a large series of patients revealed that EGFR expression, which varied considerably among HNSCCs, was a strong independent prognostic indicator for OS and DFS and a robust predictor for LR relapse but not for distant metastasis. Expand
Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase*
The data implicate a novel function of the EGFR during DNA repair processes and radiation-induced activation of DNA-PK, inhibited DNA repair, and increased radiosensitivity of treated cells. Expand
Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor.
In vitro and in vivo results indicate that in vitro SC-236 induces U251 apoptotic cell death and enhances the radiosensitivity of the surviving cells, suggesting that the selective inhibition of COX-2 combined with radiation has potential as a cancer treatment. Expand
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.
  • L. Milas, K. Mason, +5 authors Z. Fan
  • Medicine
  • Clinical cancer research : an official journal of…
  • 1 February 2000
It is concluded that C225 anti-EGFR antibody enhances tumor radioresponse by multiple mechanisms that may involve direct and indirect actions on tumor cell survival. Expand
Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance?
  • H. Choy, L. Milas
  • Medicine
  • Journal of the National Cancer Institute
  • 1 October 2003
The literature is reviewed to identify the rationale and experimental foundation supporting the use of cyclooxygenase-2 (COX-2) inhibitors with standard radiotherapy regimens in current clinical trials and to determine whether therapies that combine COx-2 inhibitors and radiation will enter randomized clinical trials. Expand
Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel.
The antitumor effect of pac litaxel was correlated with paclitaxel-induced apoptosis and base-line apoptosis, but not with mitotic arrest. Expand
Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate.
Data suggest that in addition to its role as a carrier for selective delivery of paclitaxel to the tumor, PG-TXL exerts distinct pharmacological actions of its own that may contribute to its remarkable antitumor efficacy. Expand
Macrophage content of murine sarcomas and carcinomas: associations with tumor growth parameters and tumor radiocurability.
Observations suggest that high TAM content could be conductive to tumor cell proliferation and could be a factor in poor tumor radioresponse. Expand
Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy.
Members of the erbB receptor tyrosine kinase family, particularly EGFR, were found to be a strong biomarker for poor prognosis and HNC resistance to RT and the value of EGFR antagonists in the combined modality setting is being addressed in clinical trials. Expand
Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor.
It is demonstrated that treatment with a selective inhibitor of COX-2 greatly enhanced tumor radioresponse without markedly affecting normal tissue radiore Sponse, indicating that COx-2 inhibitors have a high potential for increasing the therapeutic ratio of radiotherapy. Expand